线粒体DNA单倍群J和K对澳大利亚人群的帕金森病并无保护作用。
Mitochondrial DNA haplogroups J and K are not protective for Parkinson's disease in the Australian community.
作者信息
Mehta Prachi, Mellick George D, Rowe Dominic B, Halliday Glenda M, Jones Michael M, Manwaring Neil, Vandebona Himesha, Silburn Peter A, Wang Jie Jin, Mitchell Paul, Sue Carolyn M
机构信息
Department of Neurology and Neurogenetics, Kolling Institute, Royal North Shore Hospital and University of Sydney, Sydney, Australia.
出版信息
Mov Disord. 2009 Jan 30;24(2):290-2. doi: 10.1002/mds.22389.
MtDNA haplogroups J and K have been associated with a decreased risk of developing Parkinson's disease (PD). To confirm this finding, we compared the distribution of mtDNA haplogroups J and K in a large sample of Australian patients with PD (n = 890) to population-based controls (n = 3,491). We assigned subjects to haplogroups J or K using standard PCR/RFLP techniques. Of the 890 subjects with PD, 10.6% were haplogroup J (95% CI 8.6-12.8, n = 94) and 7.1% were haplogroup K (95% CI 5.5-8.9, n = 63). In our controls, 10.2% belonged to haplogroup J (95% CI 9.2-11.2, n = 356), and 7.8% were in haplogroup K (95% CI 6.9-8.7, n = 272). There was no significant difference in the prevalence of mtDNA haplogroup J or K in PD patients compared to population-based controls. Our findings indicate that mtDNA haplogroups J and K are not associated with a lower risk of PD.
线粒体DNA单倍群J和K与患帕金森病（PD）风险降低有关。为证实这一发现，我们比较了澳大利亚大量帕金森病患者样本（n = 890）与基于人群的对照组（n = 3491）中线粒体DNA单倍群J和K的分布情况。我们使用标准的聚合酶链反应/限制性片段长度多态性（PCR/RFLP）技术将受试者归类为单倍群J或K。在890名帕金森病患者中，10.6%为单倍群J（95%置信区间8.6 - 12.8，n = 94），7.1%为单倍群K（95%置信区间5.5 - 8.9，n = 63）。在我们的对照组中，10.2%属于单倍群J（95%置信区间9.2 - 11.2，n = 356），7.8%为单倍群K（95%置信区间6.9 - 8.7，n = 272）。与基于人群的对照组相比，帕金森病患者中线粒体DNA单倍群J或K的患病率没有显著差异。我们的研究结果表明，线粒体DNA单倍群J和K与较低的帕金森病风险无关。
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