Simen-Kapeu Aline, Kataja Vesa, Yliskoski Merja, Syrjänen Kari, Dillner Joakim, Koskela Pentti, Paavonen Jorma, Lehtinen Matti
National Public Health Institute, Youth Sexual Health Unit, Oulu, Finland.
Scand J Infect Dis. 2008;40(9):745-51. doi: 10.1080/00365540801995360.
The natural history of oncogenic human papillomavirus (HPV) infections results from interactions of the virus, the host, and multiple cofactors. We studied the association between humoral immune response to HPV and smoking in 191 HPV infected women prospectively. Two follow-up samples (first and last) were analysed for serum cotinine levels, IgA and IgG antibodies to HPV16 and 18, and Chlamydia trachomatis using ELISA methods. HPV DNA analyses were also performed, and HPV16/18 antibodies were detectable in 23 of 40 (57.5%) HPV DNA-positive women. We performed age-stratified analyses and found that young smokers were less likely to develop HPV16/18 antibodies than non-smokers (OR: 0.2, 95% CI 0.0-0.9). Furthermore, they had a significantly decreased tendency of maintaining constant HPV16/18 IgG antibody positivity by the end of the follow-up (OR: 0.1, 95% CI 0.0-0.8). Smoking did not affect the development of HPV antibody responses in women over 30 y of age. Our results suggest that smoking may induce impaired antibody response in HPV16/18-infected young women.
致癌性人乳头瘤病毒（HPV）感染的自然病程是病毒、宿主及多种辅助因素相互作用的结果。我们前瞻性地研究了191名HPV感染女性体内HPV体液免疫反应与吸烟之间的关联。使用酶联免疫吸附测定（ELISA）方法对两份随访样本（首次和末次）进行血清可替宁水平、针对HPV16和18的IgA及IgG抗体以及沙眼衣原体检测。同时进行HPV DNA分析，在40名HPV DNA阳性女性中有23名（57.5%）可检测到HPV16/18抗体。我们进行了年龄分层分析，发现年轻吸烟者比非吸烟者更不易产生HPV16/18抗体（比值比：0.2，95%置信区间0.0 - 0.9）。此外，到随访结束时，他们维持HPV16/18 IgG抗体阳性的趋势显著降低（比值比：0.1，95%置信区间0.0 - 0.8）。吸烟对30岁以上女性HPV抗体反应的产生没有影响。我们的结果表明，吸烟可能会导致HPV16/18感染的年轻女性抗体反应受损。
