King Madeleine V, Marsden Charles A, Fone Kevin C F
Institute of Neuroscience, School of Biomedical Sciences, Medical School, Queen's Medical Centre, University of Nottingham, Nottingham NG7 2UH, UK.
Trends Pharmacol Sci. 2008 Sep;29(9):482-92. doi: 10.1016/j.tips.2008.07.001.
The serotonergic system is implicated in the neurobiological control of learning and memory, both in healthy individuals and pathological disorders, although the underlying mechanisms remain elusive. After the cloning and characterization of serotonin, or 5-hydroxytryptamine (5-HT), receptors and the resultant development of selective agonist and antagonist compounds and transgenic receptor-knockout mice, our understanding of the role of various serotonin receptors in learning and memory has improved. 5-HT(1A), 5-HT4 and 5-HT6 receptors are densely expressed in brain regions innervated by serotonergic projections from the raphe nuclei and are associated with learning and memory. Here, we review the evidence that compounds acting on these receptors can have positive effects on learning and memory, and we discuss the potential mechanisms involved. This information raises the possibility that such compounds could be developed as adjunct therapeutics with existing treatments to improve learning and memory deficits, which are core symptoms of Alzheimer's disease, schizophrenia and depression.
血清素能系统参与了健康个体以及病理疾病中学习和记忆的神经生物学控制，尽管其潜在机制仍不清楚。在血清素（即5-羟色胺，5-HT）受体被克隆和鉴定，以及由此开发出选择性激动剂和拮抗剂化合物和转基因受体敲除小鼠之后，我们对各种血清素受体在学习和记忆中的作用的理解有了提高。5-HT(1A)、5-HT4和5-HT6受体在中缝核发出的血清素能投射所支配的脑区中密集表达，并与学习和记忆相关。在这里，我们综述了作用于这些受体的化合物可对学习和记忆产生积极影响的证据，并讨论了其中涉及的潜在机制。这些信息增加了这样一种可能性，即此类化合物可被开发为现有治疗方法的辅助疗法，以改善学习和记忆缺陷，而这些缺陷是阿尔茨海默病、精神分裂症和抑郁症的核心症状。
