Karpouza Angeliki, Samouilidou Elisabeth, Karagiannis Stefanos, Kostopoulou Vasiliki, Sotiropoulou Maria, Roma Eleftheria, Petraki Kalliopi, Michopoulos Spyros
Department of Biochemistry, Alexandra Hospital, Athens, Greece.
Scand J Gastroenterol. 2008 Aug;43(8):922-8. doi: 10.1080/00365520802008132.
The association between Helicobacter pylori (H. pylori) infection and serum lipid profile is still controversial. The aim of this study was to determine any possible relationship between H. pylori infection and the lipid profile of patients with upper gastrointestinal symptoms.
Consecutively selected 20-70 year-old dyspeptic patients who had undergone esophagogastroduodenoscopy were evaluated for H. pylori infection using both the CLO test and Giemsa staining. Serum total cholesterol (C), HDL-C, LDL-C, apo-A1, apo-B and triglyceride levels were measured.
A total of 137 patients (median age 52.0 years) were studied. Total cholesterol levels were lower in H. pylori-infected patients than in H. pylori-negative patients (mean +/- SEM: 199.3 +/- 5.9 versus 212.6 +/- 4.6 mg/dl, p = 0.08). Patients with duodenal ulcer (DU) had significantly lower levels of all measured lipidemic parameters including cholesterol, with the exception of triglycerides, in comparison with either H. pylori-positive or -negative dyspeptic patients (cholesterol: 177.6 +/- 6.5 versus 214.6 +/- 4.2 mg/dl, p < 0.0001). However, there was no difference in the total cholesterol/HDL-C ratio between DU patients and the rest of the dyspeptic patients.
Among H. pylori-positive and H. pylori-negative patients there was no difference in lipid profile apart from a trend towards total cholesterol levels being lower in H. pylori-positive patients. However, cholesterol, HDL-C, LDL-C, apo-A and apo-B were all decreased in DU patients even though this reduction did not result in a fall in the total cholesterol/HDL-C ratio. The etiologic factor differentiating the lipid profiles among dyspeptics only in H. pylori-positive patients carrying a DU could be dietetic, microbial, genetic or a combination of all three.
幽门螺杆菌（H. pylori）感染与血脂谱之间的关联仍存在争议。本研究的目的是确定H. pylori感染与有上消化道症状患者血脂谱之间的任何可能关系。
对连续入选的20 - 70岁接受过食管胃十二指肠镜检查的消化不良患者，使用CLO试验和吉姆萨染色评估H. pylori感染情况。测量血清总胆固醇（C）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、载脂蛋白A1（apo-A1）、载脂蛋白B（apo-B）和甘油三酯水平。
共研究了137例患者（中位年龄52.0岁）。H. pylori感染患者的总胆固醇水平低于H. pylori阴性患者（均值±标准误：199.3±5.9 vs 212.6±4.6 mg/dl，p = 0.08）。与H. pylori阳性或阴性消化不良患者相比，十二指肠溃疡（DU）患者所有测量的血脂参数水平均显著降低，包括胆固醇，但甘油三酯除外（胆固醇：177.6±6.5 vs 214.6±4.2 mg/dl，p < 0.0001）。然而，DU患者与其他消化不良患者的总胆固醇/HDL-C比值无差异。
在H. pylori阳性和阴性患者中，除了H. pylori阳性患者总胆固醇水平有降低趋势外，血脂谱无差异。然而，DU患者的胆固醇、HDL-C、LDL-C、apo-A和apo-B均降低，尽管这种降低并未导致总胆固醇/HDL-C比值下降。仅在携带DU的H. pylori阳性患者中区分消化不良患者血脂谱的病因可能是饮食、微生物、遗传因素或三者的组合。
