Tomii Yasuhiro, Kondo Masaki, Hosomi Akiko, Nagakane Yoshinari, Shiga Kensuke, Nakagawa Masanori
Department of Neurology, Kyoto Prefectural University of Medicine.
Rinsho Shinkeigaku. 2008 Oct;48(10):742-5. doi: 10.5692/clinicalneurol.48.742.
We present two patients (case 1: a 78-year-old right-handed woman, case 2: a 66-year-old right-handed woman) with suspected transient global amnesia. Both patients showed sudden onset amnesia that appeared to resolve within 24 hours, and they showed no abnormal findings on electroencephalography or single photon emission tomography. However, the results of the Wechsler Memory Scale-Revised (WMS-R) on the ninth (case2) or tenth day (case1) after the onset indicated memory impairment. And diffusion-weighted magnetic resonance imaging (DWI) revealed a unilateral high-intensity area in the hippocampus, leading to the diagnosis of hippocampal infarction in both patients. Case 1 had a left hippocampal lesion and exhibited impairment of predominantly verbal memory, while case 2 had a right hippocampal lesion and demonstrated impairment of predominantly visual memory. When evaluating a patient with suspected transient global amnesia, imaging of the hippocampus and tests on memory function after an appropriate interval from the onset are often helpful in establishing a correct diagnosis.
我们报告了两名疑似短暂性全面性遗忘症的患者（病例1：一名78岁右利手女性，病例2：一名66岁右利手女性）。两名患者均表现为突然发作的遗忘症，且似乎在24小时内缓解，脑电图或单光子发射断层扫描均未发现异常。然而，发病后第九天（病例2）或第十天（病例1）的韦氏记忆量表修订版（WMS-R）结果显示存在记忆障碍。弥散加权磁共振成像（DWI）显示海马区有单侧高强度区域，从而诊断两名患者均为海马梗死。病例1左侧海马区有病变，主要表现为言语记忆受损，而病例2右侧海马区有病变，主要表现为视觉记忆受损。在评估疑似短暂性全面性遗忘症的患者时，海马区成像以及发病后适当时间间隔后的记忆功能测试通常有助于做出正确诊断。
