使用聚合物负载的无环缩醛连接体设计与合成芳氧基链烷醇胺类G蛋白偶联受体拮抗剂文库。

Design and synthesis of a G-protein-coupled receptor antagonist library of aryloxyalkanolamines using a polymer-supported acyclic acetal linker.

作者信息

Roberge Jacques Y, Harikrishnan Lalgudi S, Kamau Muthoni G, Ruan Zheming, Van Kirk Katy, Liu Yalei, Cooper Christopher B, Poss Michael A, Dickson John K, Gavai Ashvinikumar V, Chao Sam T, Leith Leslie W, Bednarz Mark S, Mathur Arvind, Kakarla Ramesh, Schnur Dora M, Vaz Roy, Lawrence R Michael

机构信息

Bristol-Myers Squibb Company, R&D, Princeton, New Jersey 08543-4000, USA.

出版信息

J Comb Chem. 2009 Jan-Feb;11(1):72-82. doi: 10.1021/cc800051u.

DOI:10.1021/cc800051u

PMID:19086798

Abstract

A G-Protein-coupled receptor-targeted library of aryloxypropanolamines and aryloxybutanolamines was efficiently executed using a novel, polymer-supported acyclic acetal linker, producing compounds in good yields and purities.

摘要

使用新型聚合物负载的无环缩醛连接基，高效构建了一个针对G蛋白偶联受体的芳氧基丙醇胺和芳氧基丁醇胺文库，所制备的化合物产率和纯度良好。