一锅多组分合成1-芳基-5-甲基-N-R2-1H-1,2,3-三唑-4-甲酰胺：一种用于组合化学的简便方法。

One-pot multicomponent synthesis of 1-aryl-5-methyl-N-R2-1H-1,2,3-triazole-4-carboxamides: an easy procedure for combinatorial chemistry.

作者信息

Pokhodylo Nazariy T, Matiychuk Vasyl S, Obushak Mykola D

机构信息

Department of Organic Chemistry, Ivan Franko National University of Lviv, Lviv, Ukraine.

出版信息

J Comb Chem. 2009 May-Jun;11(3):481-5. doi: 10.1021/cc900012w.

DOI:10.1021/cc900012w

PMID:19382757

Abstract

A convenient synthetic protocol was elaborated for creation of combinatorial libraries of 1-(R(1)-phenyl)-5-methyl-N-R(2)-1H-1,2,3-triazole-4-carboxamides. As starting materials, commercially available or readily prepared azides, amines, and diketene were selected for the reaction which has proceeded in a one-pot system with high yields and in short time.

摘要

已精心设计了一种便捷的合成方案，用于创建1-(R(1)-苯基)-5-甲基-N-R(2)-1H-1,2,3-三唑-4-甲酰胺的组合库。作为起始原料，选择了市售的或易于制备的叠氮化物、胺和双乙烯酮用于该反应，该反应在一锅法体系中进行，产率高且时间短。