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在癌症小鼠模型中使用生物共轭物进行分子成像。

Molecular imaging with bioconjugates in mouse models of cancer.

作者信息

Mather Stephen

机构信息

Barts and The London Queen Mary's School of Medicine and Dentistry, Centre for Cancer Imaging Institute of Cancer and the CR-UK Clinical Centre, St. Bartholomew's Hos, United Kingdon.

出版信息

Bioconjug Chem. 2009 Apr;20(4):631-43. doi: 10.1021/bc800401x.

Abstract

The definition of molecular imaging provided by the Society of Nuclear Medicine is "the visualization, characterization and measurement of biological processes at the molecular and cellular levels in humans and other living systems". This review gives an overview of the technologies available for and the potential benefits from molecular imaging at the preclinical stage. It focuses on the use of imaging probes based on bioconjugates and for reasons of brevity confines itself to discussion of applications in the field of oncology, although molecular imaging can be equally useful in many fields including cardiovascular medicine, neurosciences, infection, and others.

摘要

核医学协会对分子成像的定义是“在人类和其他生物系统中,对分子和细胞水平的生物过程进行可视化、表征和测量”。本综述概述了临床前阶段可用于分子成像的技术及其潜在益处。它重点关注基于生物共轭物的成像探针的应用,出于篇幅考虑,仅局限于讨论肿瘤学领域的应用,尽管分子成像在包括心血管医学、神经科学、感染等在内的许多领域同样有用。

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