Sommer David B, Stacy Mark A
Movement Disorders Center, Duke University Medical Center, DUMC Box 3333, Durham, NC 27710, USA.
Expert Rev Neurother. 2008 Dec;8(12):1829-39. doi: 10.1586/14737175.8.12.1829.
Parkinson's disease (PD) is a common, debilitating neurodegenerative disorder that creates a significant burden for patients, family members and society at large. Major unmet needs include effective therapies that could favorably modify the underlying pathogenetic processes in PD, and better control of motor and nonmotor symptoms in advanced-stage disease. This review examines the current state of development of potential PD therapies, including dopaminergic therapies, modulators of adenosine and glutamate receptors, cell-based therapies, genetic therapies and device-based therapies. In addition, research into potential neuroprotective agents and pipeline therapies for nonmotor symptoms of PD are summarized.
帕金森病（PD）是一种常见的、使人衰弱的神经退行性疾病，给患者、家庭成员以及整个社会带来了沉重负担。主要未满足的需求包括能够有效改变帕金森病潜在致病过程的疗法，以及更好地控制晚期疾病的运动和非运动症状。本综述探讨了帕金森病潜在疗法的当前发展状况，包括多巴胺能疗法、腺苷和谷氨酸受体调节剂、基于细胞的疗法、基因疗法以及基于设备的疗法。此外，还总结了针对帕金森病非运动症状的潜在神经保护剂和在研疗法的研究情况。
