Simuni Tanya, Lyons Kelly E, Pahwa Rajesh, Hauser Robert A, Comella Cynthia, Elmer Lawrence, Weintraub Daniel
Department of Neurology, Northwestern University, Parkinson's Disease and Movement Disorders Center, Chicago, Ill, USA.
Eur Neurol. 2009;61(4):206-15. doi: 10.1159/000197104. Epub 2009 Jan 29.
The management of early Parkinson's disease (PD) involves the treatment of motor symptoms, and, increasingly, non-motor symptoms. Given the fast pace of clinical research in PD, clinicians are faced with the challenge of integrating the latest findings into the ongoing care of individual PD patients. Part 1 of this 2-part article reviews efficacy and safety data for the newest PD treatment options, as well as for established therapies. Part 2 of the article, presented here, reviews key data relevant to the assessment of potential neuroprotective therapies and the treatment of non-motor symptoms.
早期帕金森病(PD)的管理涉及运动症状的治疗,并且越来越多地涉及非运动症状的治疗。鉴于帕金森病临床研究的快速发展,临床医生面临着将最新研究结果纳入个体帕金森病患者持续治疗的挑战。这篇分两部分的文章的第1部分回顾了最新帕金森病治疗选择以及既定疗法的疗效和安全性数据。本文呈现的第2部分回顾了与潜在神经保护疗法评估和非运动症状治疗相关的关键数据。