Li Rong, Qiao Jie, Liu Ping, Ma Cai-Hong, Wang Hai-Yan, Lian Ying, Gao Ling
Reproductive Medical Center, Peking University Third Hospital, Beijing 100083, China.
Zhonghua Fu Chan Ke Za Zhi. 2008 Aug;43(8):563-6.
To analyze the clinical outcomes of patients treated with in vitro fertilization and embryo transfer (IVF-ET) and influence factors of pregnancy rate.
We retrospectively analyzed the clinical data of 12,491 cycles, including 6,832 fresh IVF/intracytoplast single sperm injection (ICSI) cycles and 5,659 frozen embryo transfer (FET) cycles from 2005 to 2007.
The clinical pregnancy rate per cycle was 32.99% (2254/6832) in fresh embryo transfer program, and the live birth rate was 25.75% (1394/5413); the early pregnant loss rate was 9.36% (211/2254), and the prenatal defect rate was 1.45% (25/1722). Through analysis of these patients' basic data, we found that the patients' age, causes for infertility, egg retrieval and cycle number affected the pregnancy rate. Using logistic regression method, we found that patients' age was the most important factor affecting pregnancy outcome. In FET cycles, the clinical pregnancy rate was 38.08% (2155/5659), significantly higher than fresh embryo transfer cycles.
IVF-ET treatment is a safe and effective method for infertility couples. However, the female age and poor ovarian response are the main factors affecting pregnancy rate. Thawed embryo transfer can increase the accumulated pregnancy rate effectively.
分析体外受精-胚胎移植（IVF-ET）患者的临床结局及妊娠率的影响因素。
回顾性分析2005年至2007年12491个周期的临床资料，其中包括6832个新鲜IVF/卵胞浆内单精子注射（ICSI）周期和5659个冻融胚胎移植（FET）周期。
新鲜胚胎移植方案中每个周期的临床妊娠率为32.99%（2254/6832），活产率为25.75%（1394/5413）；早期妊娠丢失率为9.36%（211/2254），出生缺陷率为1.45%（25/1722）。通过分析这些患者的基础资料，发现患者年龄、不孕原因、取卵情况及周期数对妊娠率有影响。采用logistic回归方法发现，患者年龄是影响妊娠结局的最重要因素。在FET周期中，临床妊娠率为38.08%（2155/5659），显著高于新鲜胚胎移植周期。
IVF-ET治疗是不孕夫妇的一种安全有效的方法。然而，女性年龄及卵巢反应不良是影响妊娠率的主要因素。冻融胚胎移植可有效提高累积妊娠率。
