碳酸锂对小鼠造血系统急性辐射损伤的预防和治疗作用
Preventive and therapeutic effects of lithium carbonate on acute radiation injury of hemopoietic system in mice.
作者信息
Ke X Y, Wang Y F, Jia T Z
机构信息
Research Center of Occupational Medicine, Third Hospital, Beijing Medical University.
出版信息
Chin Med J (Engl). 1991 Jan;104(1):54-9.
PMID:1908759
Abstract
The administration of Li2CO3 to female LACA mice for three consecutive days before or after 4Gy whole body gamma-irradiation appeared to have both preventive and therapeutic effects on radiation-induced leucopenia, especially on the depression of CFU-GM. It is effective in small dosage, short course, and even when given 24 hours after irradiation.
摘要
在4Gy全身γ射线照射前或照射后，连续三天给雌性LACA小鼠施用碳酸锂，似乎对辐射诱导的白细胞减少症，尤其是对集落形成单位 - 粒细胞巨噬细胞（CFU - GM）的抑制，具有预防和治疗作用。它在小剂量、短疗程时有效，甚至在照射后24小时给药也有效。
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