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碳酸锂对小鼠造血系统急性辐射损伤的预防和治疗作用

Preventive and therapeutic effects of lithium carbonate on acute radiation injury of hemopoietic system in mice.

作者信息

Ke X Y, Wang Y F, Jia T Z

机构信息

Research Center of Occupational Medicine, Third Hospital, Beijing Medical University.

出版信息

Chin Med J (Engl). 1991 Jan;104(1):54-9.

PMID:1908759
Abstract

The administration of Li2CO3 to female LACA mice for three consecutive days before or after 4Gy whole body gamma-irradiation appeared to have both preventive and therapeutic effects on radiation-induced leucopenia, especially on the depression of CFU-GM. It is effective in small dosage, short course, and even when given 24 hours after irradiation.

摘要

在4Gy全身γ射线照射前或照射后,连续三天给雌性LACA小鼠施用碳酸锂,似乎对辐射诱导的白细胞减少症,尤其是对集落形成单位 - 粒细胞巨噬细胞(CFU - GM)的抑制,具有预防和治疗作用。它在小剂量、短疗程时有效,甚至在照射后24小时给药也有效。

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