Zhuang Ya-ling, Wei Lang-hua, Wang Wen, Huang Li-li
Woman's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, CHINA.
Zhonghua Yi Xue Za Zhi. 2008 Aug 26;88(33):2372-4.
To evaluate the security and effectiveness of uterine artery embolization (UAE) in treatment of pregnancy in uterine caesarean scar compared with medicine treatment.
Sixty patients with pregnancies in uterine caesarean scar were divided into medicine group (n = 31) that received intravenous injection of methotrexate (MTX) 100 mg once or MTX 20 mg once a day for 5 days as the first course, received the second course when the serum beta-human chorionic gonadotropin (HCG) decreased to the level as < 50%, and then underwent uterine curettage; and UAE group (n = 29) that underwent catheterization into the left uterine artery and then uterine curettage 48h after the successful embolization. The bleeding volume during suction curettage, side effects, admission day, and menstruation recover time were recorded.
The hospital stay of the UAE group was (14.4 +/- 1.67) days, significantly shorter than that of the medicine group [(39.3 +/- 4.71) days, P < 0.05]. No patient had to receive hysterectomy in the UAE group but 2 in the medicine group underwent hysterectomy. Seven patients showed liver dysfunction and 8 patients had nausea and slight vomit in the medicine group, and 15 patients with fever and 10 with light post-embolization syndromes were found in the UAE group. Menstruation resumed normal in all patients of the 2 groups one or two months later.
With the advantage of low risk of heavy bleeding and shorter admission day, UAE is safe and effective in treatment of pregnancy in uterine caesarean scar.
