Li Min, He Xiao-Guang, Qu Shen-Hong, Zhan Hong-Mou, Yang Yi-Bing, Xu Xin, Si Yong-Feng
Department of Otorhinolaryngology, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China.
Zhonghua Yi Xue Za Zhi. 2008 Sep 9;88(34):2399-402.
To explore the changes and clinical implications of plasma resistin level in obstructive sleep apnea hypopnea syndrome (OSAHS).
Plasma resistin level was measured by radioimmunoassay in 30 obese OSAHS patients (obese OSAHS group), 7 in the low apnea hypopnea index (AHI) subgroup, 9 in the medium AHI subgroup, and 14 in the high AHI subgroup, 30 obese subjects (obese group), and 28 normal healthy adults (control group). Stepwise multiple linear regression analysis was conducted to determine the correlation of plasma resistin level with body mass index (BMI), body fat percentage, waist to hip ratio (WHR), fasting blood glucose (FBG), blood lipid, AHI, and lowest arterial oxygen saturation (LSaO(2)).
The plasma resistin levels of the obese OSAHS group and obese group were (8.48 +/- 1.44) and (7.60 +/- 1.53) microg/L respectively, both significantly higher than that of the control group [(5.78 +/- 1.62) microg/L, both P < 0.05], and that of the obese OSAHS group was significantly higher than that of the obese group (P < 0.05). The plasma resistin level of the high AHI obese OSAHS subgroup was (9.60 +/- 0.51) microg/L, significantly higher than those of the medium and low AHI obese OSAHS subgroups [(7.96 +/- 1.06) and (6.90 +/- 1.32) microg/L respectively, both P < 0.01]. Correlation analysis demonstrated that the fasting plasma resistin level was positively correlated with BMI, neck circumference, waist circumference, WHR, FBG, total cholesterol, triglyceride, and AHI (r = 0.52, 0.66, 0.74, 0.52, 0.59, 0.48, 0.46, and 0.80, all P < 0.05); and negatively correlated with high-density lipoprotein cholesterol and LSaO(2) (r = -0.52, r = -0.60, both P < 0.01). A stepwise multiple linear regression analysis showed that AHI was the most significant contributing factor for the increased plasma resistin level in the obese OSAHS group (R(2) = 0.618).
Plasma resistin level in obese OSAHS patients are increased, and are positively correlated with AHI. It may be used as an important biological index to evaluate the severity of OSAHS.
探讨阻塞性睡眠呼吸暂停低通气综合征（OSAHS）患者血浆抵抗素水平的变化及其临床意义。
采用放射免疫法测定30例肥胖OSAHS患者（肥胖OSAHS组）血浆抵抗素水平，其中低呼吸暂停低通气指数（AHI）亚组7例，中等AHI亚组9例，高AHI亚组14例；30例肥胖者（肥胖组）；28例正常健康成年人（对照组）。采用逐步多元线性回归分析确定血浆抵抗素水平与体重指数（BMI）、体脂百分比、腰臀比（WHR）、空腹血糖（FBG）、血脂、AHI及最低动脉血氧饱和度（LSaO₂）的相关性。
肥胖OSAHS组和肥胖组血浆抵抗素水平分别为（8.48±1.44）和（7.60±1.53）μg/L，均显著高于对照组[（5.78±1.62）μg/L，P均<0.05]，且肥胖OSAHS组高于肥胖组（P<0.05）。高AHI肥胖OSAHS亚组血浆抵抗素水平为（9.60±0.51）μg/L，显著高于中等和低AHI肥胖OSAHS亚组[分别为（7.96±1.06）和（6.90±1.32）μg/L，P均<0.01]。相关性分析显示，空腹血浆抵抗素水平与BMI、颈围、腰围、WHR、FBG、总胆固醇、甘油三酯及AHI呈正相关（r=0.52、0.66、0.74、0.52、0.59、0.48、0.46及0.80，P均<0.05）；与高密度脂蛋白胆固醇及LSaO₂呈负相关（r=-0.52，r=-0.60，P均<0.01）。逐步多元线性回归分析显示，AHI是肥胖OSAHS组血浆抵抗素水平升高的最主要影响因素（R²=0.618）。
肥胖OSAHS患者血浆抵抗素水平升高，且与AHI呈正相关。其可作为评估OSAHS严重程度的重要生物学指标。
