阻塞性睡眠呼吸暂停低通气综合征患者的血清脂联素水平

Serum adiponectin level in patients with obstructive sleep apnea hypopnea syndrome.

作者信息

Zhang Xi-Long, Yin Kai-Sheng, Mao Hui, Wang Hong, Yang Yu

机构信息

Department of Respiratory Medicine, First Affiliated Hospital, Nanjing Medical University, Nanjing 210029, China.

出版信息

Chin Med J (Engl). 2004 Nov;117(11):1603-6.

PMID:15569472

Abstract

BACKGROUND

Adiponectin, secreted by adipocytes, has been found to be associated with diabetes, obesity and some cardiovascular diseases. Obstructive sleep apnea hypopnea syndrome (OSAHS) is also closely related to obesity and easily complicated with diabetes and some cardiovascular diseases. This study was carried out to explore the change of serum adiponectin level in patients with OSAHS.

METHODS

Polysomnography was performed in 71 patients with OSAHS (OSAHS group) and 26 simple obese controls (control group). The two groups had no significant difference in age and body mass index (BMI). Radioimmunoassy was used to test serum adiponectin level.

RESULTS

Serum adiponectin level was significantly lower in OSAHS group [(5.03 +/- 1.01) mg/L] than that in the control group [(7.09 +/- 1.29) mg/L, P < 0.05]. The differences between two groups were independent of gender. In OSAHS groups, serum adiponectin levels were negatively correlated with apnea hypopnea index (AHI) (r = -0.78, P < 0.01), BMI (r = -0.13, P < 0.05), waist circumference (r = -0.36, P < 0.01), and neck circumference (r = -0.42, P < 0.01), but positively correlated with the minimal pulse oxyhemoglobin saturation (r = 0.48, P < 0.01).

CONCLUSION

OSAHS may contribute to the decrease of serum adiponectin level independent of obesity.

摘要

背景

脂肪细胞分泌的脂联素已被发现与糖尿病、肥胖症及一些心血管疾病有关。阻塞性睡眠呼吸暂停低通气综合征（OSAHS）也与肥胖症密切相关，且易并发糖尿病和一些心血管疾病。本研究旨在探讨OSAHS患者血清脂联素水平的变化。

方法

对71例OSAHS患者（OSAHS组）和26例单纯肥胖对照者（对照组）进行多导睡眠图监测。两组在年龄和体重指数（BMI）方面无显著差异。采用放射免疫分析法检测血清脂联素水平。

结果

OSAHS组血清脂联素水平[（5.03±1.01）mg/L]显著低于对照组[（7.09±1.29）mg/L，P<0.05]。两组间差异与性别无关。在OSAHS组中，血清脂联素水平与呼吸暂停低通气指数（AHI）（r=-0.78，P<0.01）、BMI（r=-0.13，P<0.05）、腰围（r=-0.36，P<0.01）及颈围（r=-0.42，P<0.01）呈负相关，但与最低脉搏血氧饱和度呈正相关（r=0.48，P<0.01）。