Ferrer Márquez Manuel, Rico Morales María del Mar, Carvia Pousaillè Carolina, Gálvez Miras Alejandra, Casado Martín Marta, Velasco Albendea Javier, Ferrer Ayza Manuel
Servicio de Cirugía General y del Aparato Digestivo, Hospital Torrecárdenas, Almería, Spain.
Cir Esp. 2008 Dec;84(6):313-7. doi: 10.1016/s0009-739x(08)75041-3.
Non-alcoholic fatty liver disease has a high prevalence among obese patients. It has been difficult to identify clear predictors of chronic liver damage, which could help in selecting patients for liver biopsy and therapeutic options. The aim of the study is to describe the liver damage in these obese patients and identify predictors of liver damage progression.
76 obese patients submitted to bariatric surgery were included. Liver biopsies were taken at the time at the time of the surgery. Clinical and biochemical variables were analyzed.
67 patients (88.1%) were found to have non-alcoholic fatty liver disease; 41 (61.2%) had simple steatosis, and 26 (38.8%) had non-alcoholic steatohepatitis. Patients with non-alcoholic steatohepatitis had significantly higher values of GGT. Non-alcoholic steatohepatitis was associated with diabetes (p < 0.01) in these patients.
Non-alcoholic fatty liver disease is highly prevalent in morbidly obese patients. Non- alcoholic steatohepatitis seems to be associated with diabetes and high values of GGT in obese patients.
非酒精性脂肪性肝病在肥胖患者中患病率很高。一直难以确定慢性肝损伤的明确预测指标，而这些指标有助于选择进行肝活检的患者以及确定治疗方案。本研究的目的是描述这些肥胖患者的肝损伤情况，并确定肝损伤进展的预测指标。
纳入76例接受减肥手术的肥胖患者。在手术时进行肝活检。分析临床和生化变量。
67例患者（88.1%）被发现患有非酒精性脂肪性肝病；41例（61.2%）有单纯性脂肪肝，26例（38.8%）有非酒精性脂肪性肝炎。非酒精性脂肪性肝炎患者的谷氨酰转肽酶（GGT）值显著更高。在这些患者中，非酒精性脂肪性肝炎与糖尿病相关（p < 0.01）。
非酒精性脂肪性肝病在病态肥胖患者中非常普遍。非酒精性脂肪性肝炎似乎与肥胖患者的糖尿病和高GGT值有关。
