Véran Olivier, Barré Marie, Casez Olivier, Vercueil Laurent
Unité neurovasculaire, CHU de Grenoble.
Psychol Neuropsychiatr Vieil. 2008 Dec;6(4):265-75. doi: 10.1684/pnv.2008.0145.
Transient global amnesia (TGA) is characterized by a severe disturbance of memory, occurring rapidly, lasting less than a day and mainly affecting elderly subjects. During its acute phase, it is characterized by a severe anterograde amnesia, partial retrograde amnesia and anxiety with repetition of the same questions. The diagnosis is purely based on patient's clinical features. Complimentary examinations are only requested when atypical symptoms are present. The pathophysiology of TGA remains unknown, but it appears to be related to transient disturbances of the perfusion and oxygenation of the hippocampal structures, following a precipitating factor (stress, effort...). Spontaneous recovery is usual in less than 24 hours and without sequelae. Relapse is rare. Nevertheless, TGA represents a psychological traumatism pathology for the patients and their family.
短暂性全面性遗忘症(TGA)的特征是记忆严重障碍,起病迅速,持续时间少于一天,主要影响老年患者。在急性期,其特征为严重的顺行性遗忘、部分逆行性遗忘以及反复询问相同问题所伴随的焦虑。诊断完全基于患者的临床特征。仅在出现非典型症状时才会要求进行辅助检查。TGA的病理生理学尚不清楚,但似乎与海马结构灌注和氧合的短暂紊乱有关,继发于一个诱发因素(压力、劳累等)。通常在24小时内自发恢复且无后遗症。复发罕见。然而,TGA对患者及其家人而言是一种心理创伤性疾病。