Department of Neurology, Hadassah Hebrew University Medical School, Jerusalem, Israel; Faculty of Medicine, Hadassah Hebrew University Medical School, Jerusalem, Israel.
Ann Neurol. 2014 May;75(5):634-43. doi: 10.1002/ana.24137. Epub 2014 May 16.
Transient global amnesia (TGA), an abrupt occurrence of severe anterograde episodic amnesia accompanied by repetitive questioning, has been known for more than 50 years. Despite extensive research, there is no clear evidence for the underlying pathophysiological basis of TGA. Moreover, there is no neuroimaging method to evaluate TGA in real time.
Here we used resting-state functional magnetic resonance imaging recorded in 12 patients during the acute phase of TGA together with connectivity and cluster analyses to detect changes in the episodic memory network in TGA.
Our results show a significant reduction in functional connectivity of the episodic memory network during TGA, which is more pronounced in the hyperacute phase than in the postacute phase. This disturbance is bilateral, and reversible after recovery. Although the hippocampus and its connections are significantly impaired, other parts of the episodic memory network are also impaired. Similar results were obtained for the analysis of the episodic memory network whether it was defined in a data-driven or literature-based manner.
These results suggest that TGA is related to a functional disturbance in the episodic memory network, and supply a neuroimaging correlate of TGA during the acute phase.
短暂性全面性遗忘症（TGA）是一种突发性的严重顺行性情景记忆障碍，伴有反复提问，这种病症已经存在了 50 多年。尽管进行了广泛的研究，但 TGA 的潜在病理生理基础仍缺乏明确的证据。此外，目前还没有神经影像学方法可以实时评估 TGA。
在这里，我们使用 12 名 TGA 急性发作期患者的静息态功能磁共振成像，结合连接性和聚类分析，来检测 TGA 中情景记忆网络的变化。
我们的结果显示，在 TGA 期间，情景记忆网络的功能连接显著减少，在超急性期比在急性期更为明显。这种干扰是双侧的，在恢复后是可逆的。尽管海马体及其连接明显受损，但情景记忆网络的其他部分也受到了影响。无论是以数据驱动还是基于文献的方式定义情景记忆网络，分析都得到了相似的结果。
这些结果表明，TGA 与情景记忆网络的功能障碍有关，并为 TGA 急性发作期间提供了神经影像学的对应物。
