Furniss C S, McClean M D, Smith J F, Bryan J, Applebaum K M, Nelson H H, Posner M R, Kelsey K T
Department of Environmental Health, Harvard School of Public Health, Boston, USA.
Ann Oncol. 2009 Mar;20(3):534-41. doi: 10.1093/annonc/mdn643. Epub 2008 Dec 15.
The risk of head and neck squamous cell carcinoma (HNSCC) associated with common human papillomavirus types has not been well defined.
We conducted a case-control study of 1034 individuals (486 incident cases diagnosed with HNSCC and 548 population-based controls matched to cases by age, gender, and town of residence) in Greater Boston, MA. Sera were tested for antibodies to human papillomavirus (HPV)6, HPV11, HPV16, and HPV18 L1.
HPV6 antibodies were associated with an increased risk of pharyngeal cancer [odds ratio (OR)=1.6, 1.0-2.5], controlling for smoking, drinking, and HPV16 seropositivity. In HPV16-seronegative subjects, high HPV6 titer was associated with an increased risk of pharyngeal cancer (OR=2.3, 1.1-4.8) and oral cancer (OR=1.9, 1.0-3.6), suggesting that the cancer risk associated with HPV6 is independent of HPV16. There was no association between smoking and alcohol use and HPV6 serostatus. Further, the risk of pharyngeal cancer associated with heavy smoking was different among HPV6-seronegative (OR 3.1, 2.0-4.8) and HPV6-seropositive subjects (OR=1.6, 0.7-3.5), while heavy drinking also appears to confer differing risk among HPV6-negative (OR 2.3, 1.5-3.7) and -positive subjects (OR=1.3, 0.6-2.9).
There may be interactions between positive serology and drinking and smoking, suggesting that the pathogenesis of human papillomavirus in HNSCC involves complex interactions with tobacco and alcohol exposure.
与常见人类乳头瘤病毒类型相关的头颈部鳞状细胞癌(HNSCC)风险尚未明确界定。
我们在马萨诸塞州大波士顿地区对1034名个体进行了一项病例对照研究(486例新诊断为HNSCC的病例以及548名按年龄、性别和居住城镇与病例匹配的基于人群的对照)。检测血清中针对人类乳头瘤病毒(HPV)6、HPV11、HPV16和HPV18 L1的抗体。
在控制吸烟、饮酒和HPV16血清阳性的情况下,HPV6抗体与咽癌风险增加相关[比值比(OR)=1.6,1.0 - 2.5]。在HPV16血清阴性的受试者中,高HPV6滴度与咽癌风险增加相关(OR = 2.3,1.1 - 4.8)以及口腔癌风险增加相关(OR = 1.9,1.0 - 3.6),这表明与HPV6相关的癌症风险独立于HPV16。吸烟和饮酒与HPV6血清状态之间无关联。此外,在HPV6血清阴性(OR 3.1,2.0 - 4.8)和HPV6血清阳性受试者(OR = 1.6,0.7 - 3.5)中,重度吸烟与咽癌风险不同,而重度饮酒在HPV6阴性(OR 2.3,1.5 - 3.7)和阳性受试者(OR = 1.3,0.6 - 2.9)中似乎也赋予不同风险。
血清学阳性与饮酒和吸烟之间可能存在相互作用,这表明人类乳头瘤病毒在HNSCC中的发病机制涉及与烟草和酒精暴露的复杂相互作用。