Rufini V, Shulkin B
Institute of Nuclear Medicine, Sacro Cuore Catholic University, Rome, Italy.
Q J Nucl Med Mol Imaging. 2008 Dec;52(4):341-50.
Radioiodinated metaiodobenzylguanidine (MIBG), or Iobenguane, was developed in the late 1970s at the Michigan University Medical Center for imaging the adrenal medulla and its diseases, and was rapidly extended to depict a wide range of tumors of neural crest origin. Because of its high and selective uptake and retention by these tumors, careful consideration was also given to the therapeutic potential of [(131)I]MIBG. Beside imaging and therapy of neuroendocrine tumors, the possibility of in vivo assessment of cardiac sympathetic neuronal activity led recently to a renewed interest for MIBG scintigraphy and this application is still expanding. In this paper, we review the evolution in the use of MIBG in more than 25 years of experimental and clinical applications, with attention also to the developments in radiochemistry and instrumentation. A literature search in PubMed based on ''metaiodobenzylguanidine or MIBG'' was conducted; from this analysis, it appears that the use of MIBG evolved from nearly exclusively oncology (both for diagnosis and therapy) to new applications mainly aimed to study the sympathetic neuronal integrity of the heart. Those currently exceed those about imaging of tumor diseases. We also report the geographic distribution of published papers.
放射性碘标记的间碘苄胍（MIBG），即碘苄胍，于20世纪70年代末在密歇根大学医学中心研发，用于肾上腺髓质及其疾病的成像，并迅速扩展到描绘各种神经嵴起源的肿瘤。由于这些肿瘤对其具有高度选择性摄取和滞留，人们也仔细考虑了[（131）I]MIBG的治疗潜力。除了神经内分泌肿瘤的成像和治疗外，体内评估心脏交感神经神经元活性的可能性最近重新引发了人们对MIBG闪烁扫描术的兴趣，并且这种应用仍在不断扩展。在本文中，我们回顾了25多年来MIBG在实验和临床应用中的使用演变，同时也关注放射化学和仪器设备的发展。我们在PubMed上基于“间碘苄胍或MIBG”进行了文献检索；从该分析来看，MIBG的使用已从几乎完全用于肿瘤学（诊断和治疗）发展到主要用于研究心脏交感神经神经元完整性的新应用。目前这些新应用已超过肿瘤疾病成像方面的应用。我们还报告了已发表论文的地理分布情况。
