羰基还原酶3（CBR3）介导9-顺式维甲酸诱导的细胞生长抑制，是口腔恶性肿瘤的潜在预后标志物。
Carbonyl Reductase 3 (CBR3) Mediates 9-cis-Retinoic Acid-Induced Cytostatis and is a Potential Prognostic Marker for Oral Malignancy.
作者信息
Ohkura-Hada Shuri, Kondoh Nobuo, Hada Akiyuki, Arai Masaaki, Yamazaki Yutaka, Shindoh Masanobu, Kitagawa Yoshimasa, Takahashi Masayuki, Ando Toshifumi, Sato Yasunori, Yamamoto Mikio
机构信息
Department of Biochemistry, National Defense Medical College, 3-2 Namiki, Tokorozawa-shi.
出版信息
Open Dent J. 2008;2:78-88. doi: 10.2174/1874210600802010078. Epub 2008 Jun 9.
Abstract
The molecular mechanisms of growth suppression by retinoic acid (RA) were examined. Our results suggest that the cytostatic effects of RA could be mediated by the activation of endogenous CBR3 gene in oral squamous cell carcinomas (OSCCs), and the expression is a potential marker for oral malignancy.
摘要
研究了视黄酸（RA）抑制生长的分子机制。我们的结果表明，RA的细胞生长抑制作用可能是通过口腔鳞状细胞癌（OSCCs）中内源性CBR3基因的激活来介导的，并且该基因的表达是口腔恶性肿瘤的一个潜在标志物。
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