Bining Harjinder J S, Santos Rui, Andrews Gordon, Forster Bruce B
Brooke Radiology Associates, Suite 100 5791 No. 3 Rd, Richmond, British Columbia, Canada, V6X 2C9.
Skeletal Radiol. 2009 May;38(5):459-65. doi: 10.1007/s00256-008-0629-y. Epub 2008 Dec 17.
This study aimed to investigate whether a commercially available time-efficient T2 mapping sequence will demonstrate findings of articular cartilage degeneration based on T2 relaxation values (RV) and color maps, using subchondral bone marrow edema (BME) as a marker for chondral damage.
The patient group consisted of 88 subjects who underwent knee magnetic resonance imaging at 1.5 T who had subchondral BME evident on fat-suppressed T2-weighted sequences. The control group was comprised of 60 subjects with no evidence of subchondral BME. A commercially available eight echo T2 relaxation sequence (acquisition time 8:36 min) was used to construct a T2 color map and to determine T2 RVs. T2 RVs were determined on cartilage overlying subchondral BME in patients and in eight pre-determined anatomical regions in controls. T2 color maps in the patient and control groups were analyzed for degree of color stratification (presence = two or more colors) at the same anatomic site as that used for T2 RV determination.
T2 RVs were significantly increased in patients compared to controls for the medial femoral condyle (MF; p < 0.01), medial patellar facet (MP; p < 0.01), lateral patellar facet (LP; p < 0.01), lateral femoral condyle (LF; p < 0.01) and lateral tibial plateau (LT; p < 0.01). Loss of color stratification was noted in patients compared to controls in the medial tibial plateau (MT; p = 0.01), LF (p < 0.01), and LT (p < 0.01). In the patient group, increase in T2 RVs was associated with corresponding decrease in color stratification in MF (p < 0.01), MT (p < 0.01), MP (p < 0.01), medial femoral trochlear groove (p = 0.02), and lateral femoral trochlear groove (p < 0.01).
Subchondral BME was associated with an increase in adjacent articular cartilage T2 RVs at some sites. Also, elevated T2 RVs were associated with loss of color stratification.
本研究旨在探讨一种市售的高效T2映射序列能否基于T2弛豫值（RV）和彩色图谱显示关节软骨退变的表现，以软骨下骨髓水肿（BME）作为软骨损伤的标志物。
患者组由88名在1.5T行膝关节磁共振成像的受试者组成，他们在脂肪抑制T2加权序列上有明显的软骨下BME。对照组由60名无软骨下BME证据的受试者组成。使用市售的八回波T2弛豫序列（采集时间8:36分钟）构建T2彩色图谱并确定T2 RVs。在患者软骨下BME上方的软骨以及对照组预先确定的八个解剖区域测定T2 RVs。分析患者组和对照组在与T2 RV测定相同解剖部位的T2彩色图谱的颜色分层程度（存在=两种或更多种颜色）。
与对照组相比，患者的股骨内侧髁（MF；p<0.01）、髌内侧关节面（MP；p<0.01）、髌外侧关节面（LP；p<0.01）、股骨外侧髁（LF；p<0.01）和胫骨外侧平台（LT；p<0.01）的T2 RVs显著增加。与对照组相比，患者在胫骨内侧平台（MT；p=0.01）、LF（p<0.01）和LT（p<0.01）出现颜色分层消失。在患者组中，MF（p<0.01）、MT（p<0.01）、MP（p<0.01）、股骨内侧滑车沟（p=0.02）和股骨外侧滑车沟（p<0.01）的T2 RVs增加与相应的颜色分层减少相关联。
软骨下BME在某些部位与相邻关节软骨T2 RVs增加相关。此外，T2 RVs升高与颜色分层消失相关。
