Spirin N N, Kasatkin D S
State Educational Institution of Higher Professional Education Yaroslavl Medical Academy, Russian Ministry of Health, Yaroslavl, Russia.
Neurosci Behav Physiol. 2009 Jan;39(1):25-30. doi: 10.1007/s11055-008-9087-1.
Changes in the emotional background make significant contributions to the clinical picture of multiple sclerosis (MS), seriously reducing patients' quality of life and hindering adaptation during the process of rehabilitation. The relationship between mental state and disease activity has been discussed in the world literature in recent years and the opinion that mental disorders in MS are pathogenetically based is increasingly widespread. The present article discusses the potential role of substances mediating immune responses-cytokines-in the effects of changes in the functional activity of the nervous system and psychoemotional status. The question of their likely involvement in the pathogenesis of the side effects of immunomodulatory therapy of MS with beta-interferons and glatiramer acetate is discussed.
情绪背景的变化对多发性硬化症（MS）的临床表现有重大影响，严重降低患者的生活质量，并在康复过程中阻碍适应。近年来，世界文献中讨论了精神状态与疾病活动之间的关系，认为MS中的精神障碍基于发病机制的观点越来越普遍。本文讨论了介导免疫反应的物质——细胞因子——在神经系统功能活动和心理情绪状态变化影响中的潜在作用。还讨论了它们可能参与MS使用β-干扰素和醋酸格拉替雷进行免疫调节治疗的副作用发病机制的问题。
