Exton Michael S, Baase Jan, Pithan Volker, Goebel Marion U, Limmroth Volker, Schedlowski Manfred
Institute for Medical Psychology, University Clinics of Essen, Germany.
Neuropsychobiology. 2002;45(4):199-204. doi: 10.1159/000063671.
Interferon-beta-1b (IFN-beta-1b) has been shown to reduce the relapse rate in patients with relapsing-remitting multiple sclerosis (MS) and disease progression in patients with secondary progressive MS. While acute administration of IFN-beta-1b is known to cause flu-like symptoms, chronic medication has been suggested to cause mood alterations and anxiety attacks, and secondary to this neuropsychological deficits that may impair daily life. It is unknown, however, whether the latter symptoms are induced by acute IFN-beta-1b administration. Therefore, we examined the impact of a single subcutaneous injection of IFN-beta-1b in 8 healthy males. In a crossover design, each subject was injected subcutaneously with either 8 million IU IFN-beta-1b or placebo (NaCl) at 8:00 h. Flu-like symptoms (body temperature, heart rate, blood pressure), mood status ['profile of mood states', Befindlichkeitsskala (BFS)] and neuropsychological performance (trail marking test, verbal memory test, d2 attention test) and were assessed at baseline, 4, 8 and 24 h after injection. IFN-beta-1b increased body temperature, heart rate and fatigue. Nevertheless, acute IFN-beta-1b injection did not impair any parameters of neuropsychological performance. Thus, although IFN-beta-1b produces physiological symptoms indicative of sickness behavior, these data suggest that IFN-beta-1b administration does not have an impact on the cognitive capacity following acute administration.
β-1b干扰素（IFN-β-1b）已被证明可降低复发缓解型多发性硬化症（MS）患者的复发率，并减缓继发进展型MS患者的疾病进展。虽然已知急性注射IFN-β-1b会引起流感样症状，但有研究表明长期用药会导致情绪改变和焦虑发作，并继发可能影响日常生活的神经心理缺陷。然而，尚不清楚后者的症状是否由急性注射IFN-β-1b引起。因此，我们研究了单次皮下注射IFN-β-1b对8名健康男性的影响。采用交叉设计，每位受试者于8:00皮下注射800万国际单位的IFN-β-1b或安慰剂（氯化钠）。在注射前、注射后4小时、8小时和24小时评估流感样症状（体温、心率、血压）、情绪状态[“情绪状态剖面图”，情绪量表（BFS）]以及神经心理表现（划消试验、言语记忆测试、d2注意力测试）。IFN-β-1b可提高体温、心率并引起疲劳。然而，急性注射IFN-β-1b并未损害任何神经心理表现参数。因此，尽管IFN-β-1b会产生表明疾病行为的生理症状，但这些数据表明急性注射IFN-β-1b对认知能力没有影响。
