Giri S N, Hollinger M A, Rice S A
Department of Veterinary Pharmacology and Toxicology, School of Veterinary Medicine, University of California, Davis 95616.
Toxicol Lett. 1991 Aug;57(3):283-90. doi: 10.1016/0378-4274(91)90202-h.
The intraperitoneal administration of thiourea (TU) to mature male rats results in a significant increase in lung vascular permeability to Evans Blue dye (EBD). On the other hand, young, sexually immature rats are resistant to this effect. The increase in lung vascular permeability in response to TU in mature rats is associated with corresponding increases in lung and plasma histamine levels. The correlation of increases in lung and plasma histamine in response to TU is similar to that reported for ammonium salts which produce similar pulmonary edema.
向成年雄性大鼠腹腔注射硫脲（TU）会导致肺血管对伊文思蓝染料（EBD）的通透性显著增加。另一方面，幼年、性未成熟的大鼠对这种效应具有抗性。成年大鼠中因TU导致的肺血管通透性增加与肺和血浆组胺水平的相应升高有关。TU作用下肺和血浆组胺增加之间的相关性与报道的产生类似肺水肿的铵盐的相关性相似。
