特布他林可预防组胺对肺通透性的影响。
Terbutaline preventing permeability effects of histamine in the lung.
作者信息
Persson C G, Ekman M, Erjefält I
出版信息
Acta Pharmacol Toxicol (Copenh). 1978 May;42(5):395-7. doi: 10.1111/j.1600-0773.1978.tb02223.x.
Abstract
In unanaesthetized guinea-pigs the effect of terbutaline on histamine-induced increase in lung weight was studied. Terbutaline 0.1 mg/kg and 0.3 mg/kg was given subcutaneously 5 min. before exposure during 60 min. to a histamine aerosol. Terbutaline markedly prevented the histamine-induced increase in lung weight. This effect is discussed in relation to the mechanism of action of mediator-induced increase in vascular permeability.
摘要
在未麻醉的豚鼠中，研究了特布他林对组胺诱导的肺重量增加的影响。在暴露于组胺气雾剂60分钟前5分钟，皮下注射0.1毫克/千克和0.3毫克/千克的特布他林。特布他林显著阻止了组胺诱导的肺重量增加。结合介质诱导血管通透性增加的作用机制对该效应进行了讨论。
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