沙特阿拉伯的结核病：本地人和非本地人群中的初始耐药和继发耐药情况。

Tuberculosis in Saudi Arabia: initial and secondary drug resistance among indigenous and non-indigenous populations.

作者信息

Zaman R

机构信息

National Guard King Khalid Hospital, Jeddah, Kingdom of Saudi Arabia.

出版信息

Tubercle. 1991 Mar;72(1):51-5. doi: 10.1016/0041-3879(91)90024-m.

DOI:10.1016/0041-3879(91)90024-m

PMID:1909061

Abstract

Resistance to six anti-mycobacterial agents rifampicin, isoniazid, streptomycin, ethambutol, p-amino salicylic acid and cycloserine was studied. Variations in the resistance pattern among Saudi, non-Saudi and a stable National Guard King Khalid Hospital (NGKKH) population were investigated. A high percentage of relapse cases, 21%, was recorded. Among the NGKKH population this figure was much lower, 9.9%. Resistance to rifampicin alone was high at 7.2% followed by streptomycin 3.3%, isoniazid 1.8%, p-amino salicylic 1.2% and cycloserine 0.8%. Resistance to rifampicin alone was higher among 'new' cases whilst combined resistance to two or more drugs was seen more often in 'old' patients. Resistance was seen more frequently among non-Saudis, both 'old' and 'new'. An unusual finding was the prevalence of rifampicin resistance among non-pulmonary isolates.

摘要

研究了对六种抗分枝杆菌药物利福平、异烟肼、链霉素、乙胺丁醇、对氨基水杨酸和环丝氨酸的耐药性。调查了沙特人、非沙特人和稳定的国民警卫队哈立德国王医院（NGKKH）人群之间耐药模式的差异。记录到复发率很高，为21%。在NGKKH人群中，这一数字要低得多，为9.9%。仅对利福平的耐药率很高，为7.2%，其次是链霉素3.3%、异烟肼1.8%、对氨基水杨酸1.2%和环丝氨酸0.8%。在“新”病例中，仅对利福平的耐药性较高，而在“老”患者中，对两种或更多药物的联合耐药性更为常见。在非沙特人（包括“老”患者和“新”患者）中，耐药情况更为常见。一个不寻常的发现是非肺部分离株中利福平耐药性的普遍存在。