Semb Synne, Nordgaard-Lassen Inge
Gastroenheden, Medicinsk Sektion, afsnit 439, Hvidovre Hospital, DK-2650 Hvidovre.
Ugeskr Laeger. 2008 Dec 8;170(50):4134-5.
The surgical first choice treatment for patients with ulcerative colitis (UC) involves total proctocolectomy with ileal pouch-anal anastomosis (IPAA). Postoperative development of pouch-related fistula is a rare complication, but it is associated with significant morbidity, a high recurrence rate and is a major cause of pouch failure. We report the use of infliximab, a monoclonal antibody to tumour necrosis factor-alpha, in three patients who developed pouch-related fistula after undergoing IPAA surgery for UC.
溃疡性结肠炎（UC）患者的手术首选治疗方法是全直肠结肠切除术加回肠贮袋肛管吻合术（IPAA）。贮袋相关瘘的术后发生是一种罕见的并发症，但它与显著的发病率、高复发率相关，并且是贮袋失败的主要原因。我们报告了3例因UC接受IPAA手术后发生贮袋相关瘘的患者使用肿瘤坏死因子-α单克隆抗体英夫利昔单抗的情况。
