Thunga Girish, Sam Kishore Gnana, Patel Dipish, Khera Kanav, Sheshadhri Subha, Bahuleyan Shibu, Vansalan Rohit, Pandit Vinay R, Manohar Chetan
Department of Pharmacy Practice, SS Cancer Hospital and Research Center, Manipal College of Pharmaceutical Sciences, Manipal 576104, India.
Am J Emerg Med. 2008 Nov;26(9):1070.e1-4. doi: 10.1016/j.ajem.2008.03.031.
The use of dapsone is increasing even though overdose is rarely reported and physicians must be aware of its toxicity and management. Mortality can occur due to methemoglobinemia and hemolytic anemia. Although activated charcoal and methylene blue are recommended, the use of hemodialysis is reported only in few studies. Literature on the kinetic profile indicates that 50% to 80% of dapsone is protein bound and indicates a possibility to dialyze the unbound form. This study describes a case of deliberate severe dapsone overdose with cyanosis, methemoglobinemia, and hemolytic anemia, which improved after repetitive hemodialysis.
尽管很少有过量服用氨苯砜的报告，但它的使用仍在增加，医生必须了解其毒性及处理方法。高铁血红蛋白血症和溶血性贫血可导致死亡。虽然推荐使用活性炭和亚甲蓝，但仅有少数研究报道了血液透析的应用。关于药代动力学特征的文献表明，50%至80%的氨苯砜与蛋白质结合，这表明有可能透析未结合形式的氨苯砜。本研究描述了一例故意严重过量服用氨苯砜导致发绀、高铁血红蛋白血症和溶血性贫血的病例，该病例在反复血液透析后病情好转。
