Schor Nina F
Departments of Pediatrics, Neurology, and Neurobiology & Anatomy, University of Rochester Medical Center, Rochester, NY, USA.
Pharmacol Ther. 2009 Mar;121(3):253-64. doi: 10.1016/j.pharmthera.2008.11.003. Epub 2008 Nov 27.
Tumors of the adult central nervous system are among the most common and most chemoresistant neoplasms. Malignant tumors of the brain and spinal cord collectively account for approximately 1.3% of all cancers and 2.2% of all cancer-related deaths. Novel pharmacological approaches to nervous system tumors are urgently needed. This review presents the current approaches and challenges to successful pharmacotherapy of adults with malignant tumors of the central nervous system and discusses novel approaches aimed at overcoming these challenges.
成人中枢神经系统肿瘤是最常见且化疗耐药性最强的肿瘤之一。脑和脊髓的恶性肿瘤合计约占所有癌症的1.3%以及所有癌症相关死亡的2.2%。迫切需要针对神经系统肿瘤的新型药理学方法。本综述介绍了目前针对成人中枢神经系统恶性肿瘤进行成功药物治疗的方法和挑战，并讨论了旨在克服这些挑战的新方法。
