Chardin P
Institut de Pharmacologie du CNRS, Valbonne, France.
Cancer Cells. 1991 Apr;3(4):117-26.
Mutated ras genes can acquire a transforming potential and are frequently detected in human tumors. The mammalian ras gene family includes at least 35 distinct members that can be divided into three main groups on the basis of their sequence similarity to ras, rho, or rab genes. All these genes encode small GTP-binding proteins. Rho proteins are implicated in actin organization and control of cell shape, probably by interacting with the cytoskeleton and intracellular membranes. Rab proteins are involved in vesicular traffic, and appear to control the translocation of vesicles from donor to acceptor membranes. The precise function of ras proteins is unknown, although the prevailing view is that they act as transducers of mitogenic signals. We propose that ras proteins, by analogy with rho and rab, are involved in the lateral segregation of multi-protein complexes at the plasma membrane, and we suggest how this process may be important for mitogenic signal transduction.
突变的ras基因可获得转化潜能，且在人类肿瘤中经常被检测到。哺乳动物的ras基因家族至少包括35个不同的成员，根据它们与ras、rho或rab基因的序列相似性可分为三大类。所有这些基因都编码小GTP结合蛋白。Rho蛋白可能通过与细胞骨架和细胞内膜相互作用，参与肌动蛋白组织和细胞形状的控制。Rab蛋白参与囊泡运输，似乎控制着囊泡从供体膜到受体膜的转运。尽管普遍观点认为ras蛋白作为有丝分裂信号的转导分子，但其确切功能尚不清楚。我们提出，与rho和rab类似，ras蛋白参与质膜上多蛋白复合物的侧向分离，并阐述了这一过程对有丝分裂信号转导可能具有的重要性。
