Roman Eve, Simpson Jill, Ansell Pat, Lightfoot Tracy, Smith Alex
Epidemiology and Genetics Unit, Department of Health Sciences, University of York, York, UK.
Blood Cells Mol Dis. 2009 Mar-Apr;42(2):126-8. doi: 10.1016/j.bcmd.2008.10.007. Epub 2008 Dec 16.
The United Kingdom Childhood Cancer Study (UKCCS) was specifically designed to investigate the potential etiological role of infections as one of its objectives and information on a number of markers of infectious exposure from multiple sources was collected (www.ukccs.org). This study found that a mother's recollections of past minor illness episodes in her children were unreliable, producing systematic case-control differences. From birth onwards children diagnosed with ALL between 2-5 years were found to have had more clinically diagnosed infectious illness episodes (not fewer) than unaffected children, with those with two or more neonatal infections being diagnosed with leukaemia around 7 months earlier than those with only one or none. The findings from these analyses and their implications for future research are reviewed and discussed in this paper.
英国儿童癌症研究（UKCCS）专门设计了一项研究，将调查感染的潜在病因作用作为其目标之一，并收集了来自多个来源的一些感染暴露标志物的信息（www.ukccs.org）。该研究发现，母亲对其子女过去轻微疾病发作的回忆不可靠，会产生系统性的病例对照差异。研究发现，从出生起，2至5岁被诊断为急性淋巴细胞白血病（ALL）的儿童比未患病儿童有更多临床诊断的感染性疾病发作（而非更少），有两次或更多新生儿感染的儿童被诊断出白血病的时间比只有一次或没有新生儿感染的儿童早约7个月。本文对这些分析结果及其对未来研究的意义进行了回顾和讨论。
