TP53 基因密码子 72 多态性与波兰患者喉癌的关系。
Contribution of polymorphism in codon 72 of TP53 gene to laryngeal cancer in Polish patients.
机构信息
Department of Biochemistry and Molecular Biology, Poznan University of Medical Sciences, 6 Swiecickiego Street, Poznań, Poland.
出版信息
Oral Oncol. 2009 Aug;45(8):683-6. doi: 10.1016/j.oraloncology.2008.10.009. Epub 2008 Dec 16.
The amino acid substitution Arg72Pro in the TP53 protein has an impact on the biochemical and biological activity of this protein, and is associated with several types of cancers. However, the Arg72Pro polymorphism exhibits inconsistent contribution as a risk factor in various cancer types. Therefore, using PCR-RFLPs, we investigated the distribution of Arg72Pro genotypes and alleles in patients with laryngeal cancer (n=123) and controls (n=300) in Poland. We observed that patients with the Pro/Pro and Arg/Pro TP53 genotypes displayed a 1.755-fold increased risk of laryngeal cancer (95% CI=1.149-2.680, P=0.0099). However, we did not find a significant increase in laryngeal cancer risk for the homozygous Pro/Pro TP53 genotype OR=2.093 (95% CI=1.046-4.192, P=0.0530). This result suggests that the TP53Pro variant may contribute to the risk of laryngeal cancer development in Polish patients.
TP53 蛋白中的氨基酸替换 Arg72Pro 会影响该蛋白的生化和生物学活性，并与多种类型的癌症相关。然而，Arg72Pro 多态性作为各种癌症类型的风险因素的贡献并不一致。因此，我们使用 PCR-RFLPs 方法，研究了波兰喉癌患者（n=123）和对照组（n=300）中 Arg72Pro 基因型和等位基因的分布。我们观察到，携带 Pro/Pro 和 Arg/Pro TP53 基因型的患者患喉癌的风险增加了 1.755 倍（95%CI=1.149-2.680，P=0.0099）。然而，我们没有发现纯合 Pro/Pro TP53 基因型与喉癌风险之间存在显著相关性（OR=2.093，95%CI=1.046-4.192，P=0.0530）。这一结果表明，TP53Pro 变体可能会增加波兰患者患喉癌的风险。
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