Xia Yu, Kudo Masatoshi, Minami Yasunori, Hatanaka Kinuyo, Ueshima Kazuomi, Chung Hobyung, Hagiwara Satoru, Inoue Tatsuo, Ishikawa Emi, Kitai Satoshi, Takahashi Shunsuke, Tatsumi Chie, Ueda Taisuke, Hayaishi Sosuke, Maekawa Kiyoshi
Department of Gastroenterology and Hepatology, Kinki University School of Medicine, Osaka, Japan.
Oncology. 2008;75 Suppl 1:99-105. doi: 10.1159/000173430. Epub 2008 Dec 17.
The purpose of this study was to investigate if Sonazoid-enhanced harmonic ultrasonography (US) could be used to evaluate the responses of hepatocellular carcinomas (HCCs) to treatment with transcatheter arterial chemoembolization (TACE).
Forty-three HCCs that had been treated by TACE were evaluated by Sonazoid-enhanced harmonic US and dynamic computed tomography (CT) approximately 1 week after their treatment. The detection rates of residual tumor blood supply using the two modalities were compared. Two months after chemoembolization, 16 of the 43 HCCs, which had no additional local treatment, were followed up with dynamic CT. The results of contrast-enhanced harmonic US and dynamic CT 1 week after chemoembolization were analyzed and compared with follow-up dynamic CT results.
The detection rates of positive enhancement with Sonazoid-enhanced harmonic US and dynamic CT 1 week after TACE were 25 (58.1%) of 43 lesions and 17 (39.5%) of 43 lesions, respectively. Sonazoid-enhanced harmonic US was significantly more sensitive than dynamic CT in depicting the residual tumor blood supply to HCCs 1 week after TACE (p < 0.01; chi(2) test). The Sonazoid-enhanced harmonic US results of the 16 lesions 1 week after chemoembolization were consistent with the follow-up results of dynamic CT 2 months after chemoembolization.
Sonazoid-enhanced harmonic US appears to be a highly sensitive and accurate modality for evaluating responses of HCCs shortly after TACE.
本研究的目的是调查索纳造影剂增强谐波超声检查（US）是否可用于评估肝细胞癌（HCC）经肝动脉化疗栓塞术（TACE）治疗后的反应。
43例接受TACE治疗的HCC患者在治疗后约1周接受索纳造影剂增强谐波超声检查和动态计算机断层扫描（CT）评估。比较两种检查方式对残留肿瘤血供的检出率。化疗栓塞术后2个月，43例HCC患者中有16例未接受额外局部治疗，接受动态CT随访。分析化疗栓塞术后1周的对比增强谐波超声检查和动态CT结果，并与随访动态CT结果进行比较。
TACE术后1周，索纳造影剂增强谐波超声检查和动态CT检查显示阳性强化的检出率分别为43个病灶中的25个（58.1%）和43个病灶中的17个（39.5%）。在描绘TACE术后1周HCC的残留肿瘤血供方面，索纳造影剂增强谐波超声检查比动态CT明显更敏感（p < 0.01；卡方检验）。化疗栓塞术后1周16个病灶的索纳造影剂增强谐波超声检查结果与化疗栓塞术后2个月的动态CT随访结果一致。
索纳造影剂增强谐波超声检查似乎是评估TACE术后短期内HCC反应的一种高度敏感且准确的检查方式。
