了解肿瘤分析并评估治疗方法。

Understanding tumor profiling and assessing treatment.

作者信息

Hyams David M

机构信息

Comprehensive Cancer Center, Desert Regional Medical Center, Palm Springs, California, USA.

出版信息

Manag Care. 2008 Jul;17(7 Suppl 7):4-8; discussion 17-8.

PMID:19093336

Abstract

Gene expression profiling allows us to look into a tumor cell to see how genetic information is communicated and affects cell behavior. Data gathered during the development of the 70-gene assay (MammaPrint) set the stage for future assay development. Recently, a 21-gene assay (Oncotype DX) was recommended by ASCO and NCCN as a standard of care for newly diagnosed, stage 1 or 2, node-negative, estrogen-receptor-positive breast cancer patients.

摘要

基因表达谱分析使我们能够深入肿瘤细胞，了解遗传信息是如何传递并影响细胞行为的。在70基因检测法（MammaPrint）研发过程中收集的数据为未来检测法的发展奠定了基础。最近，美国临床肿瘤学会（ASCO）和美国国立综合癌症网络（NCCN）推荐一种21基因检测法（Oncotype DX），作为新诊断的、1期或2期、淋巴结阴性、雌激素受体阳性乳腺癌患者的护理标准。