Department of General Biochemistry, Institute of Biochemistry, University of Lodz, Lodz, Poland.
Physiol Res. 2009;58(5):623-633. doi: 10.33549/physiolres.931566. Epub 2008 Nov 4.
In the article, the actions of homocysteine (Hcys) and its metabolite - cyclic thioester - homocysteine thiolactone (HTL) on complex process of hemostasis, which regulates the flowing properties of blood, are described. Possible interaction of Hcys and HTL with endothelial cells, blood platelets, plasmatic fibrinogen and plasminogen, as the important major components of hemostasis are also discussed. The modification of hemostatic proteins (N-homocysteinylated or S-homocysteinylated proteins) induced by Hcys or its thiolactone, and links of homocysteine or homocysteine thiolactone to "NO metabolism seem to be the main reason of biotoxicty of homocysteine in cardiovascular diseases.
本文描述了同型半胱氨酸（Hcys）及其代谢产物——环状硫酯——同型半胱氨酸硫内酯（HTL）在调节血液流动特性的止血复杂过程中的作用。还讨论了 Hcys 和 HTL 与血管内皮细胞、血小板、血浆纤维蛋白原和纤溶酶原等止血的重要主要成分之间可能的相互作用。Hcys 或其硫内酯诱导的止血蛋白的修饰（N-同型半胱氨酸化或 S-同型半胱氨酸化蛋白），以及同型半胱氨酸或同型半胱氨酸硫内酯与“NO 代谢”的联系，似乎是同型半胱氨酸在心血管疾病中产生生物毒性的主要原因。
