动脉调节因子被淋巴管吸收。
Arterial regulators taken up by lymphatics.
作者信息
Shawber Carrie J, Kitajewski Jan
机构信息
Department of Obstetrics/Gynecology, Herbert Irving Comprehensive Cancer Center, Columbia University Medical Center, New York, New York 10032, USA.
出版信息
Lymphat Res Biol. 2008;6(3-4):139-43. doi: 10.1089/lrb.2008.1024.
Abstract
We present three examples of key genes that function in arterial specification that have recently been implicated in lymphatic development; ephrinB2, FoxC2, and Notch. In arterial cell fate determination, Foxc2 regulates both Notch and Notch ligand expression. In turn, Notch signal activation in arteries drives expression of ephrinB2. It will be interesting to determine if the regulatory relationships between these pathways found in arterial development are relevant to understanding lymphatic development, that is, we ask whether arterial regulators are also key regulators of lymphatic development.
摘要
我们展示了三个在动脉特化中起作用且最近与淋巴管发育有关的关键基因实例；即ephrinB2、FoxC2和Notch。在动脉细胞命运决定过程中，Foxc2调节Notch及其配体的表达。反过来，动脉中的Notch信号激活驱动ephrinB2的表达。确定在动脉发育中发现的这些信号通路之间的调控关系是否与理解淋巴管发育相关将是很有趣的，也就是说，我们要问动脉调节因子是否也是淋巴管发育的关键调节因子。
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