Garmy-Susini Barbara, Varner Judith A
Moores USCD Cancer Center, University of California, San Diego, California.
Lymphat Res Biol. 2008;6(3-4):155-63. doi: 10.1089/lrb.2008.1011.
The lifelong dedication of Dr. Judah Folkman to understand how tumors co-opt vasculature to promote tumor growth and spread resulted in the development of an astounding body of knowledge and development of new clinical therapeutics for cancer. Angiogenesis is a critical point in the development and dissemination of most human tumors. Tumor-associated lymphangiogenesis also plays an important role in mediating tumor spread to lymph nodes. The molecular regulations of these processes are complex, and many key molecular families have been implicated in the regulation of angiogenesis and lymphangiogenesis. By regulating cell-cell and cell-matrix contacts, integrins participate in blood and lymphatic vessel growth by promoting endothelial cell migration and survival. Understanding the underlying mechanisms by which integrins promote tumor-associated blood and lymphatic vessel development might provide important modalities for the therapeutic intervention of metastatic spread. This review focuses on the role of integrins in angiogenesis and lymphangiogenesis. Integrins represent potential targets for pharmacological agents and open new avenues for the control of metastatic spread in the treatment of malignancies. This article is dedicated to the memory of Dr. Judah Folkman, an amazing and caring teacher, scientist, physician, and friend.
朱达·福克曼博士毕生致力于了解肿瘤如何利用脉管系统促进肿瘤生长和扩散，这带来了大量惊人的知识，并推动了癌症新临床疗法的发展。血管生成是大多数人类肿瘤发生和扩散的关键环节。肿瘤相关的淋巴管生成在介导肿瘤扩散至淋巴结过程中也发挥着重要作用。这些过程的分子调控很复杂，许多关键分子家族都与血管生成和淋巴管生成的调控有关。整合素通过调节细胞间和细胞与基质的接触，促进内皮细胞迁移和存活，从而参与血管和淋巴管的生长。了解整合素促进肿瘤相关血管和淋巴管发育的潜在机制，可能为转移性扩散的治疗干预提供重要方式。本综述聚焦于整合素在血管生成和淋巴管生成中的作用。整合素是药物的潜在靶点，为控制恶性肿瘤转移扩散开辟了新途径。本文谨献给朱达·福克曼博士，一位了不起且充满关怀的教师、科学家、医生和朋友。
