Coppus Antonia M W, Evenhuis Heleen M, Verberne Gert-Jan, Visser Frank E, Oostra Ben A, Eikelenboom Piet, van Gool Willem A, Janssens A Cecile J W, van Duijn Cornelia M
Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, the Netherlands.
J Am Geriatr Soc. 2008 Dec;56(12):2311-6. doi: 10.1111/j.1532-5415.2008.01999.x.
The longer life expectancy now experienced by persons with Down syndrome (DS) makes it necessary to know the factors influencing survival in older persons with this syndrome. In a prospective longitudinal cohort study of dementia and mortality, 506 persons with DS aged 45 and older were followed for a mean of 4.5 years (range 0.0-7.6 years). Cognitive and social functioning were tested at baseline and annual follow-up. The diagnosis of dementia was determined according to a standardized protocol. Cox proportional hazards modeling was used for survival analysis. Relative preservation of cognitive and functional ability is associated with better survival in this study population. Clinically, the most important disorders in persons with DS that are related to mortality are dementia, mobility restrictions, visual impairment, and epilepsy but not cardiovascular diseases. Also, level of intellectual disability and institutionalization are associated with mortality.
如今，唐氏综合征（DS）患者预期寿命的延长使得了解影响该综合征老年患者生存的因素变得很有必要。在一项关于痴呆症和死亡率的前瞻性纵向队列研究中，对506名45岁及以上的唐氏综合征患者进行了平均4.5年（范围为0.0 - 7.6年）的随访。在基线和每年的随访中对认知和社会功能进行测试。根据标准化方案确定痴呆症的诊断。采用Cox比例风险模型进行生存分析。在该研究人群中，认知和功能能力的相对保留与更好的生存相关。临床上，唐氏综合征患者中与死亡率相关的最重要疾病是痴呆症、行动受限、视力障碍和癫痫，而非心血管疾病。此外，智力残疾程度和机构化与死亡率相关。
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