Stevanović M, Jordović B, Uskoković D
Institute of Technical Sciences of the Serbian Academy of Sciences and Arts, 11000 Belgrade, Serbia.
J Microsc. 2008 Dec;232(3):511-6. doi: 10.1111/j.1365-2818.2008.02150.x.
Poly(DL-lactide-co-glycolide) powder composed of uniform particles with the mean particle size in the range of 110-170 nm was obtained from commercial granules. Ascorbic acid in different concentrations was encapsulated into the poly(DL-lactide-co-glycolide) particles. Degradation of the latter in terms of morphological changes in the physiological solution was followed. Within a period of 2 months, the particles completely degrade and all the ascorbic acid is released. The samples were characterized by ultraviolet spectroscopy and scanning electron microscopy.
