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坏疽性脓皮病:先前健康儿童铜绿假单胞菌败血症的一个重要特征。

Ecthyma gangrenosum: an important feature of pseudomonal sepsis in a previously well child.

作者信息

Goolamali S I, Fogo A, Killian L, Shaikh H, Brathwaite N, Ford-Adams M, Macfarlane S

机构信息

Department of Dermatology, King's College Hospital, Denmark Hill, London, UK.

出版信息

Clin Exp Dermatol. 2009 Jul;34(5):e180-2. doi: 10.1111/j.1365-2230.2008.03020.x. Epub 2009 Dec 15.

Abstract

Ecthyma gangrenosum is a rare, distinctive skin disorder associated with potentially fatal underlying pseudomonal sepsis. Although typically occurring in neutropenic or immunocompromised patients, it can occasionally affect healthy children. The appearances are characteristic with small indurated vesicular papules progressing rapidly to infarcted necrotic areas with surrounding erythema and a typical black eschar. In young children, these are often accompanied by fever and diarrhoea. The absence of suppuration and slough distinguishes it from the more recognized pyoderma gangrenosum. Lesions can occur at any site although are most commonly found over the buttocks, limbs, axillae and perineum. We describe the case of a 28-month-old, previously well child who presented with typical features of ecthyma gangrenosum secondary to Pseudomonas infection who responded to appropriate antibiotic treatment. Despite a thorough search, no underlying cause was found. Early recognition and prompt treatment with antipseudomonal antibiotics is vital to reduce morbidity and potential mortality.

摘要

坏疽性脓皮病是一种罕见的、独特的皮肤疾病,与潜在致命的基础假单胞菌败血症相关。虽然通常发生在中性粒细胞减少或免疫功能低下的患者中,但偶尔也会影响健康儿童。其表现具有特征性,小的硬结性水疱丘疹迅速发展为梗死性坏死区域,周围有红斑和典型的黑色焦痂。在幼儿中,这些通常伴有发热和腹泻。无化脓和脱屑可将其与更常见的坏疽性脓皮病区分开来。病变可发生在任何部位,尽管最常见于臀部、四肢、腋窝和会阴。我们描述了一名28个月大、此前健康的儿童病例,该儿童表现出由假单胞菌感染引起的坏疽性脓皮病的典型特征,经适当的抗生素治疗后有反应。尽管进行了全面检查,但未发现潜在病因。早期识别并及时使用抗假单胞菌抗生素治疗对于降低发病率和潜在死亡率至关重要。

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