Biscaye Stephanie, Demonchy Diane, Afanetti Mickael, Dupont Audrey, Haas Herve, Tran Antoine
Pediatric Hospitals of Nice CHU-Lenval, Nice, France.
Medicine (Baltimore). 2017 Jan;96(2):e5507. doi: 10.1097/MD.0000000000005507.
Ecthyma gangrenosum (Eg) is a necrotic lesion that is mostly seen in immunocompromised patients. It reflects a severe sepsis, possibly caused by Pseudomonas aeruginosa (Pa).
A healthy 3-year-old girl admitted to the Pediatric Emergency Department presented a sepsis-associated purpura with neurological and respiratory distress.
An empiric antibiotherapy (anti-meningococcal) was prescribed.
Forty-eight hours after admission, blood and wound cultures were positive for Pa. As a result, the decision was made to change the antibiotic therapy.Unfortunately, on day 3, the patient died. Exhaustive immunologic tests are presently being carried out.
Eg caused by Pa is uncommon in healthy children, and purpura sepsis is usually caused by Neisseria meningitides infection.
Eg should be recognized rapidly so that the appropriate treatment can be prescribed as quickly as possible.
坏疽性脓皮病(Eg)是一种坏死性病变,多见于免疫功能低下的患者。它反映了一种严重的脓毒症,可能由铜绿假单胞菌(Pa)引起。
一名3岁健康女童因出现与脓毒症相关的紫癜并伴有神经和呼吸窘迫症状被送往儿科急诊科。
给予经验性抗生素治疗(抗脑膜炎球菌)。
入院48小时后,血液和伤口培养物检测显示Pa呈阳性。因此,决定更改抗生素治疗方案。不幸的是,第3天患者死亡。目前正在进行全面的免疫学检查。
由Pa引起的Eg在健康儿童中并不常见,紫癜性脓毒症通常由脑膜炎奈瑟菌感染引起。
应迅速识别Eg,以便尽快开出适当的治疗方案。