Lederman Michael M, Jump Robin, Pilch-Cooper Heather A, Root Michael, Sieg Scott F
Department of Medicine, Case Western Reserve University, 1100 Euclid Ave, Cleveland, OH 44118, USA.
Retrovirology. 2008 Dec 18;5:116. doi: 10.1186/1742-4690-5-116.
With the continuing march of the AIDS epidemic and little hope for an effective vaccine in the near future, work to develop a topical strategy to prevent HIV infection is increasingly important. This stated, the track record of large scale "microbicide" trials has been disappointing with nonspecific inhibitors either failing to protect women from infection or even increasing HIV acquisition. Newer strategies that target directly the elements needed for viral entry into cells have shown promise in non-human primate models of HIV transmission and as these agents have not yet been broadly introduced in regions of highest HIV prevalence, they are particularly attractive for prophylaxis. We review here the agents that can block HIV cellular entry and that show promise as topical strategies or "virustats" to prevent mucosal transmission of HIV infection.
随着艾滋病疫情的持续蔓延，且在近期内研发出有效疫苗的希望渺茫，制定一种局部预防策略以防止艾滋病毒感染的工作变得越发重要。话虽如此，大规模“杀微生物剂”试验的记录一直令人失望，非特异性抑制剂要么无法保护女性免受感染，甚至还会增加艾滋病毒的感染几率。直接针对病毒进入细胞所需元件的新策略在艾滋病毒传播的非人灵长类动物模型中已显示出前景，而且由于这些药物尚未在艾滋病毒感染率最高的地区广泛应用，它们在预防方面特别具有吸引力。我们在此回顾那些能够阻断艾滋病毒进入细胞，并有望作为局部预防策略或“病毒抑制剂”来防止艾滋病毒黏膜传播的药物。
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