Liu Jian, Guo Wei, Yang Rong-li, Tang Xiao-dong, Yang Yi
Department of Orthopedic Oncology, Peking University People's Hospital, Beijing 100044, China.
Zhonghua Wai Ke Za Zhi. 2008 Aug 1;46(15):1166-70.
To determine the prognostic factors that influence survival of patients with non-metastatic, high-grade osteosarcoma of the extremities.
The data of 72 patients treated between June 2003 and June 2007, was retrospectively evaluated in relation to many factors including gender, age, etc.
Tumor necrosis was significantly related to gender, tumor volume change, tumor margin and T2 signal intensity of the extraosseous component of bone sarcomas. Multivariate analysis, tumor necrosis was only related to tumor volume change. Upon multivariate analysis, good histologic response was related to the outcome of patients.
Event free survival is related to the tumor necrosis, the level of alkaline phosphatase and the change of T2 signal of the extraosseous component. Tumor necrosis is related to the volume change after preoperative chemotherapy. These factors must be considered when deciding risk-adapted treatments for patients with osteosarcoma.
确定影响肢体非转移性、高级别骨肉瘤患者生存的预后因素。
回顾性评估2003年6月至2007年6月期间接受治疗的72例患者的数据，涉及性别、年龄等诸多因素。
肿瘤坏死与骨肉瘤的性别、肿瘤体积变化、肿瘤边界及骨外成分的T2信号强度显著相关。多因素分析显示，肿瘤坏死仅与肿瘤体积变化有关。多因素分析表明，良好的组织学反应与患者的预后相关。
无事件生存期与肿瘤坏死、碱性磷酸酶水平及骨外成分的T2信号变化有关。肿瘤坏死与术前化疗后的体积变化有关。在为骨肉瘤患者确定风险适应性治疗方案时，必须考虑这些因素。
