Min Hong-wei, Li Zi-rong, Cheng Li-ming, Shi Zhen-cai
Graduate School, Peking Union Medical College, Beijing 100730, China.
Zhonghua Wai Ke Za Zhi. 2008 Aug 1;46(15):1171-3.
To detect the blood perfusion of the necrotic area and the femoral head and neck junction in the patients diagnosed as osteonecrosis of femoral head (ONFH) with laser doppler flowmetry (LDF).
From 2007 to 2008, 50 patients with ONFH 82 hips were performed core decompression and autologous stem cells transplantation. Group A was for ARCO stage II 46 hips (IIA 6 hips, IIB 22 hips, IIC 18 hips), and Group B was for stage III 36 hips (IIIA 20 hips, IIIB 10 hips, IIIC 6 hips). Blood perfusion of necrotic area and femoral head and neck junction with LDP were detected during the operation. Statistical analysis was made.
In Group A, the perfusion volume of necrotic area was (30.2 +/- 3.0) PU, and the perfusion volume of femoral head and neck junction was (103.4 +/- 4.4) PU. In Group B, the perfusion volume of necrotic area was (30.6 +/- 2.8) PU, and the perfusion volume of femoral head and neck junction was (103.4 +/- 3.9) PU. In Group A and Group B, the perfusion volume of necrotic area was lower than that of femoral head and neck junction, and the difference was significant (P < 0.01).
LDF can effectively detect that the perfusion volume of ONFH decreased, which provides a theoretical basis in order to further study the pathogenesis of ONFH. Meanwhile, there is application value of LDF on the study of ONFH.
应用激光多普勒血流仪（LDF）检测股骨头坏死（ONFH）患者坏死区域及股骨头颈交界处的血流灌注情况。
2007年至2008年，对50例ONFH患者的82髋行髓芯减压及自体干细胞移植术。A组为ARCO II期46髋（IIA期6髋，IIB期22髋，IIC期18髋），B组为III期36髋（IIIA期20髋，IIIB期10髋，IIIC期6髋）。术中用LDP检测坏死区域及股骨头颈交界处的血流灌注情况，并进行统计学分析。
A组坏死区域灌注量为（30.2±3.0）PU，股骨头颈交界处灌注量为（103.4±4.4）PU。B组坏死区域灌注量为（30.6±2.8）PU，股骨头颈交界处灌注量为（103.4±3.9）PU。A组和B组坏死区域灌注量均低于股骨头颈交界处，差异有统计学意义（P<0.01）。
LDF能有效检测出ONFH灌注量降低，为进一步研究ONFH发病机制提供了理论依据。同时，LDF在ONFH研究中有应用价值。
