[维生素D受体基因多态性：与青少年特发性脊柱侧弯女孩的低骨密度无关联]
[Vitamin D receptor gene polymorphisms: no association with low bone mineral density in adolescent idiopathic scoliosis girls].
作者信息
Chen Wen-jun, Qiu Yong, Zhu Feng, Zhu Ze-zhang, Sun Xu, Liu Zhen, Chen Zhi-jun
机构信息
Department of Spinal Surgery, the Affiliated Drum Tower Hospital of Medical School, Nanjing University, Nanjing 210008, China.
出版信息
Zhonghua Wai Ke Za Zhi. 2008 Aug 1;46(15):1183-6.
OBJECTIVE
To investigate the association of vitamin D receptor (VDR) gene polymorphisms with low bone mineral density (BMD) in adolescent idiopathic scoliosis (AIS) girls.
METHODS
Blood samples were obtained from 146 AIS girls and 146 healthy girls. Anthropometric parameters of AIS group including age, body height, weight and Cobb angle were all recorded. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to detect and analyze VDR gene distributions of AIS group and control group. BMD of the lumbar spine (L(1)-L(4)) and proximal femur were measured using dual energy x-ray absorptiometry in AIS group.
RESULTS
The frequency of Bb genotype was significantly higher in patients than that in controls (P < 0.05). There was no distinction among the lumbar spine and proximal femur BMD of each genotype in AIS group (P > 0.05).
CONCLUSION
VDR gene polymorphisms have no association with the low spine lumbar and proximal femur BMD in AIS girls.
目的
探讨维生素D受体（VDR）基因多态性与青少年特发性脊柱侧凸（AIS）女孩低骨密度（BMD）的相关性。
方法
采集146例AIS女孩和146例健康女孩的血样。记录AIS组的人体测量参数，包括年龄、身高、体重和Cobb角。采用聚合酶链反应-限制性片段长度多态性（PCR-RFLP）技术检测并分析AIS组和对照组的VDR基因分布。在AIS组中，使用双能X线吸收法测量腰椎（L1-L4）和股骨近端的骨密度。
结果
患者中Bb基因型的频率显著高于对照组（P < 0.05）。AIS组各基因型的腰椎和股骨近端骨密度之间无差异（P > 0.05）。
结论
VDR基因多态性与AIS女孩的腰椎和股骨近端低骨密度无关。
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