监测抗疟药物疗效：当前的挑战。
Monitoring antimalarial drug efficacy: current challenges.
机构信息
Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, MD 21201, USA.
出版信息
Curr Infect Dis Rep. 2009 Jan;11(1):59-65. doi: 10.1007/s11908-009-0009-3.
Abstract
Access to effective antimalarial therapy has increased dramatically. As malaria-endemic countries begin to use artemisinin-based combination therapy (ACT) to treat malaria, detecting the emergence and spread of resistance has become more complicated but also more urgent. Clinical efficacy studies may not be sensitive enough to detect the failure of a single component of combination therapy while standardized criteria for in vitro resistance and validated molecular markers are not yet available to many currently deployed drugs. This review discusses the challenges to various methods to monitor antimalarial drug resistance and proposes an integrated approach to the rapid detection and characterization of resistance to ACTs should it arise.
摘要
有效抗疟疗法的可及性大大提高。随着疟疾流行国家开始使用青蒿素为基础的联合疗法（ACT）来治疗疟疾，检测抗药性的出现和传播变得更加复杂，但也更加紧迫。临床疗效研究可能不够敏感，无法检测到联合疗法中单一成分的失效，而目前许多已部署的药物还没有用于体外抗药性的标准化标准和经过验证的分子标记物。本文讨论了监测抗疟药物耐药性的各种方法所面临的挑战，并提出了一种综合方法，以便在 ACT 出现耐药性时快速检测和鉴定其耐药性。
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