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Drug-Resistant Malaria: The Era of ACT.抗药性疟疾：ACT 时代。
Curr Infect Dis Rep. 2010 May;12(3):165-73. doi: 10.1007/s11908-010-0099-y.
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Local emergence in Amazonia of C580Y mutants associated with artemisinin resistance.在亚马逊地区出现与青蒿素耐药性相关的 C580Y 突变体。
Elife. 2020 May 12;9:e51015. doi: 10.7554/eLife.51015.
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The clinical impact of artemisinin resistance in Southeast Asia and the potential for future spread.东南亚青蒿素耐药性的临床影响及未来传播潜力。
FEMS Microbiol Rev. 2017 Jan;41(1):34-48. doi: 10.1093/femsre/fuw037. Epub 2016 Sep 8.
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Geographic expansion of artemisinin resistance.青蒿素耐药性的地理扩张。
J Travel Med. 2019 Jun 1;26(4). doi: 10.1093/jtm/taz030.
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Artemisinin-resistant malaria.抗青蒿素疟疾
Clin Microbiol Rev. 2024 Dec 10;37(4):e0010924. doi: 10.1128/cmr.00109-24. Epub 2024 Oct 15.
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Antimalarial drug resistance: linking Plasmodium falciparum parasite biology to the clinic.抗疟药物耐药性：将恶性疟原虫生物学与临床联系起来
Nat Med. 2017 Aug 4;23(8):917-928. doi: 10.1038/nm.4381.
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Artemisinin-Resistant Plasmodium falciparum Malaria.抗青蒿素疟原虫疟疾。
Microbiol Spectr. 2016 Jun;4(3). doi: 10.1128/microbiolspec.EI10-0013-2016.
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Plasmodium falciparum resistance to artemisinin-based combination therapies: A sword of Damocles in the path toward malaria elimination.恶性疟原虫对青蒿素联合疗法的耐药性：疟疾消除之路上的达摩克利斯之剑。
Parasite. 2018;25:24. doi: 10.1051/parasite/2018021. Epub 2018 Apr 20.
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Plasmodium falciparum Resistance to Artemisinin Derivatives and Piperaquine: A Major Challenge for Malaria Elimination in Cambodia.恶性疟原虫对青蒿素衍生物和哌喹的耐药性：柬埔寨疟疾消除面临的重大挑战。
Am J Trop Med Hyg. 2016 Dec 7;95(6):1228-1238. doi: 10.4269/ajtmh.16-0234. Epub 2016 Oct 17.
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Pharmacotherapy for artemisinin-resistant malaria.抗青蒿素疟疾的药物治疗。
Expert Opin Pharmacother. 2021 Dec;22(18):2483-2493. doi: 10.1080/14656566.2021.1959913. Epub 2021 Jul 29.
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A review of natural products as a source of next-generation drugs against apicomplexan parasites.天然产物作为抗顶复门寄生虫的下一代药物来源的综述。
NPJ Antimicrob Resist. 2025 Jun 6;3(1):51. doi: 10.1038/s44259-025-00119-x.
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High Frequency of Artemisinin Partial Resistance Mutations in the Great Lakes Region Revealed Through Rapid Pooled Deep Sequencing.通过快速混合深度测序揭示大湖地区青蒿素部分抗性突变的高频率
J Infect Dis. 2025 Feb 4;231(1):269-280. doi: 10.1093/infdis/jiae475.
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Evaluation of the binding interactions between Plasmodium falciparum Kelch-13 mutant recombinant proteins with artemisinin.评价疟原虫 Kelch-13 突变重组蛋白与青蒿素的结合相互作用。
PLoS One. 2024 Aug 15;19(8):e0306975. doi: 10.1371/journal.pone.0306975. eCollection 2024.
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Effect of the Affordable Medicines Facility for malaria (AMFm) on the availability of antimalarials in Nigeria.疟疾可负担药品设施（AMFm）对尼日利亚抗疟药可及性的影响。
Malariaworld J. 2015 May 9;6:5. doi: 10.5281/zenodo.10870095. eCollection 2015.
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The current status of infrastructure for monitoring the efficacy of antimalarial therapeutics in Zambia.赞比亚抗疟治疗效果监测基础设施的现状。
Malariaworld J. 2014 Sep 23;5:9. doi: 10.5281/zenodo.10887816. eCollection 2014.
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High frequency of artemisinin partial resistance mutations in the great lake region revealed through rapid pooled deep sequencing.通过快速混合深度测序揭示大湖地区青蒿素部分抗性突变的高频率
medRxiv. 2024 May 1:2024.04.29.24306442. doi: 10.1101/2024.04.29.24306442.
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Low Complexity of Infection Is Associated With Molecular Persistence of in Kenya and Tanzania.感染的低复杂性与肯尼亚和坦桑尼亚的分子持续性相关。
Front Epidemiol. 2022 Jun 6;2:852237. doi: 10.3389/fepid.2022.852237. eCollection 2022.
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Imidazolopiperazine (IPZ)-Induced Differential Transcriptomic Responses on Wild-Type and IPZ-Resistant Mutant Parasites.咪唑并哌嗪（IPZ）诱导的野生型和 IPZ 抗性突变体寄生虫的差异转录组反应。
Genes (Basel). 2023 Nov 24;14(12):2124. doi: 10.3390/genes14122124.
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coiaf: Directly estimating complexity of infection with allele frequencies.coiaf：直接用等位基因频率估计感染复杂度。
PLoS Comput Biol. 2023 Jun 9;19(6):e1010247. doi: 10.1371/journal.pcbi.1010247. eCollection 2023 Jun.
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Evolution of Plasmodium falciparum antimalarial drug resistance markers post-adoption of artemisinin-based combination therapies in Yaounde, Cameroon.喀麦隆雅温得采用青蒿素类复方疗法后恶性疟原虫抗疟药耐药标志物的演变。
Int J Infect Dis. 2023 Jul;132:108-117. doi: 10.1016/j.ijid.2023.03.050. Epub 2023 Apr 6.
本文引用的文献
1
Decreased in vitro susceptibility of Plasmodium falciparum isolates to artesunate, mefloquine, chloroquine, and quinine in Cambodia from 2001 to 2007.2001 至 2007 年柬埔寨青蒿琥酯、甲氟喹、氯喹和奎宁对疟原虫分离株的体外敏感性降低。
Antimicrob Agents Chemother. 2010 May;54(5):2135-42. doi: 10.1128/AAC.01304-09. Epub 2010 Mar 1.
2
Plasmodium falciparum genome-wide scans for positive selection, recombination hot spots and resistance to antimalarial drugs.恶性疟原虫全基因组范围的正选择、重组热点分析和抗疟药物耐药性研究。
Nat Genet. 2010 Mar;42(3):268-71. doi: 10.1038/ng.528. Epub 2010 Jan 31.
3
In vivo parasitological measures of artemisinin susceptibility.体内寄生虫学青蒿素敏感性测量。
J Infect Dis. 2010 Feb 15;201(4):570-9. doi: 10.1086/650301.
4
Hyperparasitaemia and low dosing are an important source of anti-malarial drug resistance.寄生虫过度感染和低剂量用药是抗疟药物产生抗药性的一个重要原因。
Malar J. 2009 Nov 11;8:253. doi: 10.1186/1475-2875-8-253.
5
Artemisinin resistance on the Thai-Cambodian border.泰柬边境的青蒿素耐药性。
Lancet. 2009 Oct 24;374(9699):1419. doi: 10.1016/S0140-6736(09)61857-2.
6
Plasmodium falciparum multidrug resistance protein 1 and artemisinin-based combination therapy in Africa.非洲恶性疟原虫多药耐药蛋白1与青蒿素联合疗法
J Infect Dis. 2009 Nov 1;200(9):1456-64. doi: 10.1086/606009.
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Measurement of adherence, drug concentrations and the effectiveness of artemether-lumefantrine, chlorproguanil-dapsone or sulphadoxine-pyrimethamine in the treatment of uncomplicated malaria in Malawi.在马拉维测量蒿甲醚-本芴醇、氯胍-氨苯砜或磺胺多辛-乙胺嘧啶治疗单纯性疟疾的依从性、药物浓度及疗效。
Malar J. 2009 Aug 26;8:204. doi: 10.1186/1475-2875-8-204.
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Artemisinin resistance in Plasmodium falciparum malaria.恶性疟原虫疟疾中的青蒿素耐药性。
N Engl J Med. 2009 Jul 30;361(5):455-67. doi: 10.1056/NEJMoa0808859.
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Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomised trial.奎宁与蒿甲醚-本芴醇治疗乌干达儿童单纯性恶性疟的疗效比较：随机试验
BMJ. 2009 Jul 21;339:b2763. doi: 10.1136/bmj.b2763.
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Artemisinin-based combination therapy for treating uncomplicated malaria.基于青蒿素的联合疗法治疗非复杂性疟疾。
Cochrane Database Syst Rev. 2009 Jul 8;2009(3):CD007483. doi: 10.1002/14651858.CD007483.pub2.
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