Wirth Michael A, Klotz Conrad, Deffenbaugh Daren L, McNulty Don, Richards Laura, Tipper Joanne L
Department of Orthopaedics, University of Texas, Health Science Center at San Antonio, San Antonio, TX 78284, USA.
J Shoulder Elbow Surg. 2009 Jan-Feb;18(1):130-7. doi: 10.1016/j.jse.2008.06.015.
Wear debris has been observed in shoulder arthroplasties that use an ultrahigh-molecular weight polyethylene (UHMWPE) glenoid component, and the biologic response to this debris contributes to aseptic loosening of the implant. The objective of this study was to assess the wear and particle morphology of a cross-linked UHMWPE prosthetic glenoid. To our knowledge, this is the first time a simulator with kinematic considerations for assessing wear has been used in a shoulder model. Shoulder wear testing was conducted on 2 groups of glenoids (n = 3 in each group) by use of an orthopaedic joint simulator to create worst-case scenario motions. One group was manufactured from conventional UHMWPE. The second was manufactured from 50-kGy cross-linked UHMWPE. The resulting wear rates for the conventional and cross-linked glenoid components were 46.7 +/- 2.6 mg/million cycles and 7.0 +/- 0.4 mg/million cycles, respectively. Particles isolated from the 2 groups showed similar morphologies; however, the calculated osteolytic potential of the cross-linked glenoid was significantly lower. The results of this study support the use of cross-linked UHMWPE glenoids in clinical applications.
在使用超高分子量聚乙烯（UHMWPE）关节盂部件的肩关节置换术中已观察到磨损碎屑，并且对这种碎屑的生物学反应会导致植入物无菌性松动。本研究的目的是评估交联UHMWPE人工关节盂的磨损情况和颗粒形态。据我们所知，这是首次在肩部模型中使用考虑运动学因素的模拟器来评估磨损。通过使用骨科关节模拟器模拟最坏情况的运动，对两组关节盂（每组n = 3）进行肩部磨损测试。一组由传统UHMWPE制成。另一组由50-kGy交联UHMWPE制成。传统和交联关节盂部件的磨损率分别为46.7±2.6毫克/百万次循环和7.0±0.4毫克/百万次循环。从两组中分离出的颗粒显示出相似的形态；然而，交联关节盂的计算溶骨潜力明显较低。本研究结果支持在临床应用中使用交联UHMWPE关节盂。
