Department of Oral and Maxillofacial Surgery, Klinikum Rechts der Isar der Technischen Universität München, Ismaninger Strasse 22, Munich, Germany.
Oral Oncol. 2009 Aug;45(8):687-91. doi: 10.1016/j.oraloncology.2008.10.011. Epub 2008 Dec 17.
The aim of this study was to investigate whether the recurrence interval influenced survival rate of patients with relapse of oral squamous cell carcinoma (OSCC). From 1992 to 2006, a total of 773 patients with OSCC treated at the Department of Oral and Maxillofacial Plastic Surgery of the Ruhr-University Bochum were reviewed. Statistical analysis included descriptive statistics, Kaplan-Meier survival analyses, receiver operating characteristic, the Youden-Index and analysis using the log-rank test and Cox-regression. The overall recurrence rate was 23.9%. Local recurrence was more common (64.9%) than locoregional recurrence (25.1%). Patients with relapse more than 18 months after completion of their primary treatment had significantly improved survival rates compared with those who relapsed within 18 months of initial treatment (20.5% vs 42.3%). A significant difference was noted in the survival rate between patients with local and locoregional recurrence (37.5% vs 21.5%). Overall survival rate after salvage was 31.9%. The interval from initial treatment to recurrence is an independent prognostic factor for OSCC patients. Patients with a recurrence interval of 18 months had a statistically significant higher probability of death than those with a recurrence interval >18 months. This information can help inform salvage treatment strategies and provide a classification of early and late recurrences.
本研究旨在探讨复发间隔是否影响口腔鳞状细胞癌（OSCC）患者的生存率。1992 年至 2006 年，回顾了在鲁尔大学波鸿分校口腔颌面整形外科接受治疗的 773 例 OSCC 患者。统计分析包括描述性统计、Kaplan-Meier 生存分析、受试者工作特征曲线、约登指数以及对数秩检验和 Cox 回归分析。总体复发率为 23.9%。局部复发（64.9%）比局部区域复发（25.1%）更为常见。与初始治疗后 18 个月内复发的患者相比，完成初始治疗后 18 个月以上复发的患者生存率显著提高（20.5% vs. 42.3%）。局部复发和局部区域复发患者的生存率存在显著差异（37.5% vs. 21.5%）。挽救治疗后的总生存率为 31.9%。从初始治疗到复发的时间间隔是 OSCC 患者的独立预后因素。复发间隔 18 个月的患者死亡的概率明显高于复发间隔>18 个月的患者。这些信息有助于为挽救治疗策略提供信息，并对早期和晚期复发进行分类。
